Knee Replacement Allergies – Nothing to Sneeze At?

Each year, hundreds of thousands of knee replacements are performed. In knee replacement, the worn ends of the bones that make up the knee joint are replaced with metal and plastic implants.  In most cases, results are excellent, however in rare cases, an immune response may arise and can become problematic.

That is, the patient may suffer from an allergy or hypersensitivity to the metallic components of the implant. Symptoms may include warmth or swelling at the knee, a skin rash and even loosening of the implant.

This complication is so rare, that its very existence has been debated. But at the 2009 annual meeting of the American Academy of Orthopaedic Surgeons, a paper was presented documenting what appear to be allergic reactions to knee replacements.

Dr. Alvin Ong et. al. recorded 19 cases from 2005-2008 where total knee replacement failures were attributed to metal sensitivity. The authors ruled out all other possible causes of implant failure and then performed a special test, the lymphocyte transformation test (LTT) which looks at a patients sensitivity to certain metals. Seventeen of the nineteen patients with failed knee replacements were tested. Ten patients recorded high sensitivity while the remaining seven indicated mild sensitivity.

Following the sensitivity testing, 16 of the patients had a second procedure where the traditional metal knee replacement was removed and replaced with a non-metallic implant (the ceramic Oxinium implant from manufacturer Smith and Nephew).  Following this knee replacement, the authors reported good results and elimination of the inflammation that was present with the traditional metal implant.

So although an allergic reaction to metal knee replacement implants may be rare, it is not unheard of. Unfortunately, diagnostic tests like LTT are relatively expensive and persons testing positive are not always symptomatic.1 In their article, Dr. Ong et. al. suggest that surgeons be mindful of the possibility of metal hypersensitivity especially when failures of implants are noted and cannot be attributed to other factors.

1 Rabin SI, Graf CN, Hopkinson, WJ, Hallab NJ “Immune Response to Implants.” 08 Mar. 2009. <>

2 Jafari SM, Della Valle CJ, Orozco F, Ong AC. “Metal Hypersensitivity Following Total Knee Arthroplasty: A Real Phenomenon?” 2009 AAOS Annual Meeting, Poster No. P134


193 Responses to “Knee Replacement Allergies – Nothing to Sneeze At?”

  1. segue17 on August 28th, 2009 2:41 pm

    Has anyone heard of a hypersensitivity or allergy to the ceramic Oxinium implant from manufacturer Smith and Nephew? I had TK in June of 2008 and following complications a revision with another (ceramic Oxinium implant from manufacturer Smith and Nephew) in March of 2009. [At the time of the revision the scar tissue/inflammation surrounding the joint was the depth equivalent to the length of my surgeons thumb...pic's if you're interested...] I am experiencing increasing fluid build up in the knee which is being aspirated to relieve the intense pressure every 4 weeks (roughly 50cc’s each time) and am now going through testing for every type of possible infection or allergy there is. I do have the ability to straighten my knee and despite the extra fluid can get about 115 degrees of flexion. I just can’t seeem to find any info about this anywhere. At 48 I am fairly young for a TK which was due to a series of injuries.

  2. Bill McCullough on October 28th, 2009 3:55 pm

    I was looking for something related to a rash in conjunction with a TKR. In 2002 I had the procedure.
    I had nine surgeries on my knee with the tenth being the replacement.
    I had everything from the carticel implant to the tibal tuberosity sic. to four or five simple scopes.
    Knee still doesn’t work but I’ll live with it. I have about 65 degrees when bending where I have 110 in the right leg.
    Anyway, shortly after the replacement I noticed a rash below the knee that I cannot get rid of. Several doctors have prescribed meds for what they think it might be but nothing works. When I asked my surgeon about it he commented he had seen that in several other cases but had no idea what it was.
    Just wondering if anyone else has had this.

  3. Paul York on January 28th, 2010 2:03 pm

    Hi all,

    I had a TK last June, I have been experiencing a rash on the outside of the knee as well as swelling and heat since then. About a week ago I started getting a rash all over my body. My surgeon is very confused as to what is happening, so has recommended I get a second opinion. I came across this website yesterday, and feel pretty sure this is what is happening to my knee.

  4. Bobbie Crowley on May 20th, 2010 9:58 pm

    My dentist removed all metal fillings because he believed the amalgum fillings could be a cause of unusuall health problems. As person with chemical allergies, is total knee replacement worth the risk?

  5. Steve Miers on August 11th, 2010 5:39 pm

    I had a tkr about 10 tears ago,Smith and Nephew, genesis 2. Swelling has been continuous. Had a blood test recently by Orthopedic Analysis and found I am alergic to Nickel. Considering another replacement, although not very excited, unsure of related health issues resulting fom the allergy. Any other resuls out there?

  6. Lisa on September 12th, 2010 11:40 am

    I had a tkr done 14 weeks ago and just started to get hives and itching around the outside of the knee. My dr. has me on a medrol dose pack (prednisone). Would an allergy to the new knee wait 12 weeks to surface. Has this happened to anyone else at this time? I’m also starting to get little hives on my fingers and arms on the same side of my body.

  7. Kathy on November 8th, 2010 7:07 pm

    I had bilateral tkr June 2010, three months later I developed a bumpy red rash surrounding my incisions. It later flattened out and spread. I currently have a round flat rash on the outside of each knee. It has also spread to my arms,back, trunk…small itchy bumps. I am taking prednisone and using
    Betamethasone Ointment on the larger patches. Benadryl helps with the itching. I am concerned about the impact on the joints and the integrity of the devices.

  8. Susan Smeal on November 9th, 2010 5:25 pm

    i had my first total knee done August13th and a week later i started to break out on my arms legs stomach back and fingers i have been itching ever since i had my other knee done on september 27th and still the same thing i have been put on creams and methylprednisolone and still nothing works im at my wits end with this and i cant find anything to stop the ithcing anyone have any ideas to help me

  9. Susan Smeal on December 9th, 2010 4:18 am

    hi to anyone reading this i had two tkr one on august 13th and the 2nd on september 27th 2010 i told my doctor about my rash, itching, and digging my body raw he said he didn’t know what it could be i went to my family doctor and he sent me for blood tests they came back normal but then he sent me to a allergy center and they tested me to see if i was allergic to the metals and sure enough i am allergic to 3 of the metals in my knee so now they have to come out so if your haveing this problem you might want to talk to your family doctor and tell them you want to be tested i wish you all the luck in the world

  10. Donna Wagner on December 28th, 2010 10:43 am

    I broke out in a rash all over my back two years ago. Since that time I get one or two on my hands. My leg with the implant is different. My lower leg and the one of many scars on my leg that they operated on are so itchy. The knee replacement I had was in 1987 so it is not just an itchy scar

  11. Donna Wagner on December 28th, 2010 11:18 am

    I have taken every steriod med they gave me and the creams nothing has helped. Until the rash just has been on my leg with the knee replacement I started to wonder. I do get the odd spot that shows up on my hands now. I am going to ask my Doctor and will get back here and let you all know what he has to say

  12. Virginia on February 3rd, 2011 2:01 pm

    I had tka more than 3 years ago and started experiencing swelling, heat and pain (worse than before the procedure) about 1 year after surgery. Finally, finally, I got my surgeon’s attention about this situation — he had been suggesting that I needed to strengthen my quads (I teach yoga, my quads are fine). I have an allergy to the nickel in the implant. I am scheduled to have my replacement revised shortly. The knee company has custom built me a knee that has no nickel in it. BTW, I never had rashes or skin irratations. So metal allergies to implants is not a myth or even perhaps as rare as we have previously thought. Lots of baby-boomers getting things replaced and we may see these problems more.

  13. Lois Clark on February 24th, 2011 8:55 pm

    I had my surgery Oct 23 2010 & my second one on Nov 3, Tkr in the right knee. Every since I had my surgery Ive been having severe pain, swelling, & walking with a limp. I have been back to my dr & he tell’s me no wrongs about my knee when I am constantly having pain & swelling in my right knee also chills & hotness in the knee, my dr tells me he don’t know why my knee is hurting & swelling, but he suggested me to get a MRI on my back, cause he thinks my back is hurting when my knee is hurting. I never had back problems before or after my surgery, so I think he is not telling me what I need to know. If there’s anyone out there that have suffer what Ive suffered & can relate to this, please Email me & tell me what I need to know. P.S. I have lost over 35 pains after my knee surgery.

  14. Nancy on February 25th, 2011 2:16 pm

    I need both my knees replaced,but I also have an allergy to metal. I can’t even wear a watch. Only gold. I worry that when they replace my knee it will get infected because of the allergy. But I am in so much pain every day because of my knees,I am at a total loss of what to do.

  15. Cher on March 3rd, 2011 3:53 am

    Hi ya’ll…I had partial knee in Mar 07…was always HOT and the swelling never really went down. Doc said I was doing fine, released ne from his treatment in Aug 07…just scheduled for check up six months out. By Oct 07 was in a lot of pain…when straightening my leg in bed, would wake me up. VERY PANIFUL. Doc did bone scan…knee was loose, (glue came undone) microfractures of tibia and bone had worn away from rubbing. They thought it was infected too. Had to have TKR Nov07 with Oxinium, Smith/Nephew. (I should have mentioned that I have reactions to metals) After TKR, anything that could have gone wrong, has. Had surgery Feb 10…totally opened it up again…cleaned out scar tissue (really bad) was in hosp. for 5 days, in CPM machine for 6 weeks. After the TKR, I get hive type rash on my knee. (only on knee) It is HOT and always puffy. Now, for the past 6 to 9 months I have been trying to figure out why I am anemic. Have had blood tests…I am not iron deficient. I have been checked for ulcers and celiac disease. All negative. I am fatigued…depressed…achey all over. I asked my doc a long time ago if I could be allergic to this knee. He said that it was nearly impossible…that I would be the first, since I have the oxinium knee. I really don’t know what to do. I would like to feel good again. I am only 52.

  16. Sharon Chandler on March 6th, 2011 8:37 pm

    Had total knee replacement Jan. 11th 2010, never worked, 7 mos.
    later still not walking, went for second opinion, doctor told me
    that the first Doctor had a bad day in the OR needed revision
    surgery, hyperextended and knee cap in wrong place with the
    ligaments needing to be the same on each side and new spacer
    bigger size done. Now, 7 months after revision, I can walk normally
    for about 10 steps and knee seems to tighten up so bad, I can
    hardly bend it. Have had deep tissue massages to break-up all
    scar tissue and nothing is working, anyone out there had similar

  17. Kathy Getz on March 8th, 2011 5:21 am

    I had a TKR done last August 2010. It was the worst pain I have ever gone through. I was in the hospital for 5 days and received 2 pints of blood. I did my physical thearpy but was making no progress with my range of motion. Finally in November 2010 my surgeon did a manipulation. It seemed to help the bending of the knee but it was still very painful. I went back to the surgeon today and told him about the constant pain and swelling. He gave me a shot of cortizone that didn’t help at all. When I asked him about an allergy to nickel he said I should have brought that to his attention before the surgery. I was appalled! Isn’t that something the doctor should ask before surgery? How was I to know an allergy to jewelry had anything to do with a knee implant? I was more focused on being able to walk without pain and I still can’t do that today. My only recourse is to have the knee redone with a replacement that does not have nickel–some kind of ceramic stuff. I am not looking forward to going through this again. If you have a TKR coming up please have the tests for nickel/metal allergies before you end up like me!

  18. Kathy Getz on March 8th, 2011 5:29 am

    I had a TKR done last August 2010. It was the worst pain I have ever gone through. I was in the hospital for 5 days and received 2 pints of blood. I did my physical thearpy but was making no progress with my range of motion. Finally in November 2010 my surgeon did a manipulation. It seemed to help the bending of the knee but it was still very painful. I went back to the surgeon today and told him about the constant pain and swelling. He gave me a shot of cortizone that didn’t help at all. When I asked him about an allergy to nickel he said I should have brought that to his attention before the surgery. I was appalled! Isn’t that something the doctor should ask before surgery? How was I to know an allergy to jewelry had anything to do with a knee implant? I was more focused on being able to walk without pain and I still can’t do that today. My only recourse is to have the knee redone with a replacement that does not have nickel–some kind of ceramic stuff. I am not looking forward to going through this again. If you have a TKR coming up please have the tests for nickel/metal allergies before you end up like me!

  19. Malcolm Toran on March 13th, 2011 11:11 am

    My wife had TKR done on 12-08-09. She has’nt been right since. Her knee hurts always to the point of crying. Thought she may have cancer…did Pet Scan, negative. Bone Scan, negative. She has headaches to the point of crying, loss of energy, constipation from taking pain pills all time. I am tired of Docs who seem not to care. Sending us everywhere, milking our Insurance and taking our money. Help us!!!!!!

  20. Gail on March 24th, 2011 12:47 pm

    I had a total knee replacement on Dec 20, 2010. Since the morning after my surgery I have had a terrible smell in my nostrils. I also feel that I have a strong body order, however no one around me can smell anything. This happens when I am exerting myself, when I get upset or nervous and also when I am having physical therapy. The only other way I can describe it is, it’s the same thing that some people experience when they eat garlic. The order actually comes out their pores.

  21. Paul on May 5th, 2011 5:23 am

    had a knee replacement 18 months ago. pain never subsided. It wasn’t in my knee, it was in the femur and tibial areas. Bone scan showed activity where metal meets bone. Rash on the outside of my knee. I can’t wear jewelry. My skin breaks out. Surgeon won’t agree that its metal alergy. Frustration!!

  22. Vivienne porter on May 5th, 2011 7:51 pm

    Had a pkr this, loosened needed total TKR h didn’t work infection I am told , but unidentified by microbiologists. Revision needed so joint removed and knee splinted for 6 weeks given broad based anti-biotics for 6 weeks followed by yet another new knee, just in-case your bored this is my third knee guess what after 5 months it’s hot swollen and painful. X rays and bloods show no infection yet again I’m limping and very uncomfortable at night and it’s no better. could this be a reaction to the metal? Interesting reading your stories and possible causes. What to do now?

  23. Pam on June 15th, 2011 1:21 pm

    I need knee replacement really, really bad and after reading all the stories I think I would rather suffer with what I am suffering now than find I have more problems. I have nickel/metal allergies and if I touch a key or something my skin will itch so bad and my skin will blister like I’ve been burned…I have tried every medicine for itch…nothing works. Finally I found a lotion made by C.O. Bigelow called Lotio Mentholus No. 002. Is a soothing topical analgesic lotion. It is cooling on my skin and if the itch is severe, after I apply the lotion I put the affected area in front of a cooling fan. IT WORKS!!!
    I think the active ingredient is camphor…It is so worth the $25.00. Find it online…

  24. Pam on June 15th, 2011 1:26 pm

    Has anyone had the Oxinium, Smith/Nephew implant with nickel/metal allergies and still had problems with rash, itching or other problems? I was thinking the Oxinium, Smith/Nephew implant might be my only hope.

  25. Angela Dossey on June 15th, 2011 8:06 pm

    Read all the responses posted very interesting. I also had problems when I had TKR in 2008 (Zimmer NexGen CR-Flex) because of a injury. The doc also found OA. After TKR swelling and itching began around incisions and incision would swell and begin to open during therapy. I then developed open lesions around incisions and on arms. Biopsies showed nothing on lesions. Last allergy test showed I have a allergy to hydroxyethyl methacrylate (bone cement glue ingredient). Now I have to have the prosthetic knee removed, all the glue removed and a cement
    free knee replaced.

  26. Melodee on July 12th, 2011 1:03 am

    My Dad had knee surgery and has suffered with a skin rash ever since. No one seems to be able to get to the bottom of it. He is so weak now from suffering so long with this rash that is over most of his body. Who can help????

  27. Vivienne porter on July 13th, 2011 11:21 am

    Has he been tested for any of the allergies people here seem to have had? if not insist he does. Poor man i’m sure we all feel for you both. I get the impression from my last follow up appointment with my surgeon that so long as the implant has taken and not loose we just have to make do with the outcome of our surgery, I’m pretty fed up with it all and wish to god I had never been persuaded to have surgery in the first instance over three years ago and three operations later, and a leg with a limited bend that inhibits my everyday life. For any one else reading this take heed.

  28. Steve Miers on July 13th, 2011 11:45 am

    I have the Smith/Nephew Joint and am allergic to it. How many others with the allergic reaction have that brand?

  29. Steve Miers on July 13th, 2011 12:34 pm


  30. Lisa Barsky on July 30th, 2011 2:27 pm

    I had 1st knee replaced left one in nov 07. Nov 9th, swollen lip. no allergic reaction to anything ever. had a fall and caused me to have right knee replaced 2008 and having infections, holes, couldnt use the CPM machine being the holes were gaping and tunneling up the incision. i have been suffering for many years and now with the rkr and the infections etc, it had caused me to swell from the elbows down! half hand, blue knuckle or fingers, huge bumps in palm and scalp, wrists feel like they are broken etc. All the pain pills never work. But I keep taking them thinking that some day they will kick in. Debating removal of both knee replacements with something that is non metal related. I do have zimmer nex gen knees. Could it be glue, cement? Not seeing ortho surgeon any longer being he blows me off. going on wednesday to see a new ortho surgeon for injections. we will see what he has to offer. i say everyday, cut my legs off. the pain is excrutiating and its sad to say that I dont remember a day without pain. Maybe someone out there can help me and share their similar stories!

  31. Pat Warner on August 23rd, 2011 7:00 pm

    I had a total knee replacement in November, in November, 2008.
    I’ve had two follow up surgeries because no matter how much P.T. I do, it won’t bend beyond 90 degrees. I continue to have pain, and an ugly, raised, red rash comes and goes at will.
    The surgeon has had me see 3 separate dermatologists and I’ve been tested for everything frm the cement to whether I’m allergic to the latex gloves used in surgery. There doesn’t seem to be an answer, nor is there any particular interest by the surgeon,

  32. Jackie Meredith on August 28th, 2011 5:50 am

    I had a TKR August 2110. When I came out of surgery, I had horrible blisters from my knee down to my ankle which turned into deep wounds that that the doctors had no answer as to why this happened.They sent a variety of doctors in to see me and took a multitude of pictures. It’s been a year and the skin from my knee down is so sensitive it keeps me awake at night. Also my foot feels so stiff it’s uncomfortable bending it. I hope time will help this part. They thought it could have been caused by the straight iodine they painted my leg with to prevent infection, but they had never had it happen before. Has anyone else had this experience. I’m still glad I had the TKR, because I am walking again.

  33. Christine on September 13th, 2011 11:55 am

    I had a left TKR done July 20, 2011 and since have had problem after problem.. I am 29 yrs old and had many previous surgeries resulting in osteo degenerative arthritis and required TKR.. Since the surgery I can not do a straight leg lift AT ALL HEEL is stuck to floor. I have to manually lift my leg to get in and out of car or anywhere else that requires this motion. The swelling is pretty bad it has improved a little but barely…. I am itchy itchy crazy itchy.. I usually just rub the sides of the knee with my palms, but i guess went crazy on it in my sleep the other night and scratched it raw…. The top 3-4 inches of the scar is bumpy and very itchy….I am not sure about the whole allergy thing, I know that i can not EVEN for a second wear fake jewellry. if i dare put a fake earing in my ear it instantly itches, gets red and hot….I hope this is not the case, but this TKR has been a nightmare from day one…. I am sure i have a little bit of nerve damage and this is y i no longer do a straight leg raise.. I do physio 3 times a week, I also work full time, have an 9 yr ld, 6 yr old and a 2 yr old, so i am very active always up and down. I dont know what to do.. I am too young for these issues, should i speak to a new surgeon or just give it more time…

  34. Pam on September 14th, 2011 12:35 am

    After reading problems I am more afraid than ever to have my knee replaced, which I really really need. But I have heard there is a new implant better than the smith and nephew. It is called the AESCULAP AS (alternative surface). It’s made for people with metal allergies. C.O. Bigelow’s – Lotio Mentholus No. 002 is the best I have found to help the itch. I itch, so bad, my skin blisters and will peel off like a burn.
    Has anyone heard of the AESCULAP AS knee?

  35. Angela Dossey on September 15th, 2011 10:19 pm

    I had TKR 2008 left knee swelled and staples came out same night of surgery blood all over sheets in hospital bed. Turns out I am allergic to Acrylic Methacrylate and antibiotic in the bone cement. Have to have another knee revision and have cement removed and another knee that requires no cement. Problem is all tkr require some kind of cement.

  36. Stevie C. on September 18th, 2011 5:30 pm

    Like segue17 above, I too had a Smith and Nephew Oxonium knee installed (Mine in 2007). I also have a nickel allergy. I’ve since suffered from the same symptoms. No rash but pain, tenderness and constant swelling, soreness and stiffness and increased pain and swelling after being up on it for several hours or even after a short time of working on a ladder or walking on uneven ground.
    I suspect the following:
    Inflammation due to an allergic reaction to the bone cement, polyethylene components, residual nickel leftover from the stainless plate and screws used to repair my broken tibial plateau (removed two months after my January 2004 fracture) or possibly the zirconium, niobium and/or zirconium dioxide surface of the femoral component.
    I’m going to an allergist this coming Tuesday (today is 09/18/2011) and I’m trying to put together a complete list of component material to be tested for. I’ve tried to get this before from S&N with no luck.
    Good luck segue17, please let us know how you are doing as will I.

  37. Jule on October 17th, 2011 2:31 am

    I had a TKR (Stryker) in June 2007. I have a severe nickel allergy but was not informed that the implant had nickel in it. My knee was always warm, swollen and had limited mobility. Had a scope in 2010 to remove scar tissue to help with mobility and developed a staph infection that two surgeries and four months of IV antibiotics couldn’t clear . The nickel caused the treatment to fail. I nearly died and the implant was removed to find the infection pooled underneath. After the surgery, I began to feel better than I had for the past 3 years. Had revision surgery January 7, 2011 with a TKR that was nickel free made of titanium. The surgery and recovery went well. My new TKR is great. Anyone doctor that does not believe metal allergies or any environmental allergies can affect a patient’s health is in denial. I have never been so sick for so long, 8 months off work. If your surgeon won’t listen, find another one who will. My new surgeon saved my life.

  38. Jim on October 22nd, 2011 2:48 am

    Had my left knee TKR done 11 months ago. Since then have had my knee drained a few times but it fills back up that night. The doc feels I may have an allergic reaction to nickel (why he didn’t test me ahead of time…who knows). Had metal allergy patch testing done but it all came back negative. Now waiting for the blood test (LTT) to see how that goes. If that’s negative he says he’ll have to go back in and see what’s going on. With all the pain and swelling anything will hopefully be positive for a better result. More later…

  39. Patrick Lange on October 27th, 2011 2:31 pm

    I have had three total knee replacements two chromium nickle and the current one is Titainium with ceramic coating. Ever since the very first one I have had pain and swelling, they aspirate it and pull bloody fluid off. They have sent these off numerous times for testing and all come back negative. Iam in constant pain everyday and this thing always has fluid on it. I have had the Senovial lining and Bursa sac removed and I still get the bloody fluid build up.

  40. Reader on November 3rd, 2011 5:57 am

    Came across this site when surfing for info on metal allergies related to dental crowns. I started reading because I have bad knees and fear that a replacement recommendation might be in my future. I will heed all of the advice and warnings about getting tested for metal allergies. I’m so sorry all of you are going through all the pain and suffering. Some of it is due to ineptitude on the part of doctors and I’m sorry to say that some of it is due to greed of both the manufacturer and medical community. Again, so sorry for all of your suffering.

  41. Kate on November 7th, 2011 2:54 am

    I’m about to start on the process that so many of you have been through. I had TKR December 2010 and I have never been in so much pain I do have all the scabby rashes, swelling, heated knee etc etc I have been feeling very unwell in myself for the last 11 months. I am hoping that something will come out of the tests that I am due to have this week. Has someone out there had the problem fixed?

  42. Pam H on November 18th, 2011 2:07 pm

    I wish I would have done better research before my TKR. It has been 7 months of hell. LTT tests show I am mainly allergic to iron. My new surgeon scoped my knee three days ago and took out tissue for analysis to be sure of whats going on before he takes the replacement out. I assumed that he would put a ceramic one in, but now I am reading that there is metal in that, too, and there are people having allergic reactions, also. Does anyone have the AESCULAP AS Columbus knee system? It looks like it could be the answer. My surgeon says that he can have a knee custom made for me. What really angers me is that I told surgeon #1 that I am highly allergic to metal. He said it wouldn’t be a problem and I believed him. Now here I am, being poisoned by the chunk of metal he put in me, facing more surgery. I wonder if I will ever be normal again. I wish I could get my old knee back!

  43. warren on November 19th, 2011 12:45 pm

    I had itching for nearly a year on the back of both knees, calves, thighs and below my waist at the back after tkr of my right knee. Calmurid, Hydrozole cream and Advantin cream and calamine lotion did not fix it, but recently Betnovate 1/5 cream fixed it in 4 days.

    I have the Smith and Nephew Genesis 2 prosthesis using the Visionaire Protocol. The flexion is +5 to +110 degrees at 11 months, after an extra bend under anaesthetic 2 weeks after the original operation.

  44. Jim on November 22nd, 2011 11:39 pm

    Had my LTT test results come back and just as I thought I’m allergic to nickel. Had the chromium/cobalt implant that has some nickel. Waiting now for workers comp to approve getting it fixed. The doc is researching whether titanium or the ceramic would work better. Probably have another new knee for Christmas again this year. Getting tired of new knees for Christmas.

  45. susan smeal on December 7th, 2011 9:32 pm

    hi all im hoping to find u all doing well i wanted tpo update you all since my last tkr i had to undergo two moew i had a bad reaction to nickle chromium and colbolt so i had two revisions in april of 2011 and all though my itching is gone thanks to pure titanium knees i still dont have the mobility i should have and i struggle everyday with the pain that dont seem to want to go away its been 8 months and i thought by now i would be squatting or just more than i was doing but no they hurt very bad but im greatful the itch is gone and im trying to get back to being normal agian but it is a everyday struggle i wish u all the very best of luck but before anyone gets this done please insist on being allergy tested its the only way of knowing and its better to be safe than sorry happy holidays to all and best of luck to you all

  46. Warren on December 13th, 2011 3:17 am

    I had Smith & Nephew Genesis2 TKR using Visionaire protocol to reduce operation time and cut bone more accurately, a year ago. 7 1/2 weeks in hospital, lots of Endone, then Oxycontin for pain, then walking stick and exercises for a total of one year. Had skin itching for a whole year, Hydrozole, Calmurid and calamine lotion did not help. Then a smart GP fixed the itch in 4-5 days with Betnovate 1/5 Cream. I can now walk up and down single steps, but the Oxycontin seems to have slowed my brain switching speed, for thing like playing the piano and seeing things quickly. Bend is now +5 to +110 degrees and no internal infections. Take 4 Amoxycillin 500mg. tablets every time I get a scratch and draw blood, then another 4x500mg. Amoxycillin 12 hours later, to stop the possibility of an infection getting into the TKR. Warren

  47. Boni on December 17th, 2011 6:06 pm

    Reply to Jackie Meredith. My father just had his knee done. Horible bruiising and blistering below the knee. Knee looks great. I insist it looks like an allergic reaction. Doctor doesn’t know what caused it. Pictures sent by a family friend to an infectious disease doctor, who also say’s looks like an allergic reaction as well. Father still in hospital, we will wait to see what the doctor says after we tell him about above opinion. Frustrating, knee itself looks good, no bruising or blistering.

  48. Leo on December 28th, 2011 12:22 pm

    I had my TKR about 6 weeks ago and have a great deal of pain on the inside of my knee, under the knee in the soft area below the back of the thigh and at the top of the calf muscle as well as the lower half of the cafe, my ankle feels like it has been sprained, and my knee all the way down to my foot has become swollen just as it was after surgery. I have been on antibiotics a week before the surgery, and the present. There is a brown discoloration about 2 inches wide and 6 inches long along the inside of my knew 3 inches above and three inches below then across the front just below the knee cap. The same area is very painful and at times even more painful if touched or I lave it on anything like a pillow or ice pack. My family doctor and my surgeon and both continue to tell me my pain should be less and less every day, and can not tell me why the discoloration, or why there is pain in areas described above. They also can not explain the swelling from the knee down (including the knee) so they continue to prescribe antibiotics, and tell me to keep taking pain pills. Has anyone experienced any of the above symptoms if so please let me know and what was done to resolve you problems.

    Thanks Leo

  49. Robert Blau on December 30th, 2011 2:08 am

    I had a De Puy Knee implant on January 19 2011.I immediately post surgery started to itch.I thought the itching was related to the pain medication.After being released from the hospital the itching continued.I then went to a dermatoligist believing I was still reacting to the pain medication.The dermatoligist gave me topical steroids.The steroids did not cure the rashes I had on my shins knee thigh arm and back.Iwent back and was diagnosed with contact dermatitis,given a steroid shot and topical steroids.The shot did provide temporary relief but the rashes soon returned in full force.I went to my family M.D.He sent me back to the dermatoligist.I was given a another steroid shot topical steroids and at a return visit tested for allergies to all the creams I was using and for nickel.No luck.I then went to an allergist and tested for everything.No results.I believe it is the knee replacement.I am now requesting the Lymphocyte transformation test. The M.D. is not familiar with the test.What labs are competent to do the test?Does anyone know? What knee manufacturer makes a non allergenic knee?What Orthopedist is the best at taking a knee out and putting a new one in?I would like a break from the rash and itching!Thanks

  50. Kim on January 6th, 2012 12:59 pm

    I am facing my 5th TKR in as many years next month. After ONE year they fail…. I am being tested for metal allergies in 2 wks. I had to find out this info myself as my OS had no cllue..which being a revision specialist shocks me (at a major teaching hospital in Boston MA). After my last surgery (a lateral release last March) I had a bad allergec reaction to the staples. This was a first and it was my 6th knee surgery. Chances are my right knee has also failed. I was told that this OS only uses one kind of knee so maybe I will have to find a dr. who can put a non metal knee in if in fact I do test positive. As a kid I could not wear nickel jewelry so I am really thinking this is the cause. Sucks that after 4 failed TKR’s this had not been brought up by any OS.

  51. Doug 84 yrs. young on January 16th, 2012 4:47 am

    TKR this past June 2011. Thanks for all the info, had a titanium knee, never had any pain, works great. However, my whole body except my hands and face have this horrible itchy,itchy and still itching rash. Did the steroids, creams,lotions, antibiotics to no avail. Was asked if I had any allergies, said “no”. If I did, I didn’t know it, don’t wear jewelry. I assumed they meant medicines. I have no intention of going thru it again at my age. Will have to try the two creams mentioned on these post. If I find relief from the itching side affects, will repost. I live with five dogs and if I’m ever lost, look for the one who does all the itching. Maybe the Vets Advantage or Program would work..hmmmmm!

  52. Jim on January 17th, 2012 4:06 am

    Just some info for anyone experiencing pain and swelling that won’t go away. Had a TKR 12/10 and after about 8 months my doctor started to think I may be having an allergic reaction. Sent me to a dermatologist who ran patch testing that all came back negative. I did some research and found there is a lab in Chicago that does blood testing for metal allergies. Had a blood sample sent back to them and after about a week I got the results. My blood was reacting to nickel. I had the chromium/cobalt implant that had traces of nickel in the alloy. Well 4 weeks ago I had revision surgery and they replaced it with an implant made from Tivanium, a titanium alloy with no nickel. The difference is like night and day and am making such progress. Went to P.T. today and already am up to 123 degrees range of motion. This may not be the cure for everyone but something to consider. The test is called a lymphocyte transformation blood test.

  53. Mr. John Joseph Sabrowski on January 26th, 2012 6:29 am

    Yes, they asked me, do you have reaction to metal. “Yes” I said back. I was not given any testing done prior or after surgery. The VA suggested I go to a local Ortho Surgery center in Rapid City, SD. I did. I got put aside by one Surgeon there. I will not say his name. He wrote and said that I said, he lied, he wrote saying I did not want an operation. I got hot under the collar, went to the H and R office and I complained. I told them that I was referred to go to their Surge center by the VA. I was walked to the door after that visit with their center’s Human Resources officer. I went home. I called back after looking up on the WWW just who were the surgeons there. I got back by phone. I got squeezed in to see another Surgeon. He told me they would take good care of me. Now, I have a rash on my right side of my right knee under and to the side of the knee cap. This rash came to me after 7 months from my operation. The day before my operation on my right knee I was given Barium and a CT scan that was done to me by the VA. After my surgery I found out that Barium is a trace metal substance that I cannot have prior or after surgery. Barium is a trace metal of a curtain sort used to illuminate. The CT scan shows that I have cists on my Kidneys, benign, not solid. I am putting a save on my rash. I also tried to heal this with Vicks-VaproRub. Also put peroxide on the rash to kill infection. Also I am taking Benadryl liquid-gels; 25 MG each, not to take more than 6 per 24 hrs

  54. PJ on February 3rd, 2012 4:26 pm

    I am sorry to hear of all the goings wrong of TKR. I too at 51 years old, 5 months ago went through a double! I can bend to 128 and have excellent straightening,can do a lot….but never without pain, swelling,burning, clicking, shooting electrical pains, aching of the knee, shin, thigh and also a bizarre veiny rash that gets worse by days end like a petechiae…it seems the legs have too much pressure. Therapy stopped me two weeks ago as they said one knee was not tracking right. I can barely get up stairs, walk more Than one block. I’ve tried two weeks to get a hold of my surgeon to no avail. One of the tops in the Chicago area that does the Visionaires, custom made. I am worse off than before my accident and years of tennis. I am scared. I have learned much from all of you and am grateful. I will start with the allergy testing. Thanks so much for sharing. I wish you all grace and healing!

  55. Pam on February 4th, 2012 2:48 pm


    I’ve heard somewhere in Chicago, but can’t get past that….

  56. Jim on February 5th, 2012 3:48 am

    I used them and they found I was allergic to nickel in my TKR….Good Luck

  57. Mr. John Joseph Sabrowski on February 6th, 2012 9:34 pm

    Thank all the people who are in what seems to me to be the same boat that I am in with this rash thing goiong on much the same. as I did read all blogs so far on my screen. My wife says it follows the nurves. I am convinced, as I have had a lump on my left bicept for two weeks that hurt. Then the rash came out in that spot. It seem what ever this rash problem is, it is very serious. Amen

  58. Tori on February 7th, 2012 6:07 am

    I had my first TKR L KNEE in 2008. Horrible experience since day one. Uncontrollable pain due to my epidural falling out and the nurses refused to listen to me. They finally got my pain under control then got me into a CPM. I barely got to 40 degrees (It took me months just to get to 90) One yr later my knee was red, hot, extremely swollen, and gave out all the time, to the point of falling. I was referred to a specialist who told me that it wasnt the right fit. He did the 2nd surgery and seems that some of the problems have resolved. But one month before the second surgery, i started having rashes. Then huge hives all over my body. In fact i had a severe breakout the day of the surgery and noone put two and two together. Now its 4 months since the second surgery, (oh i should tell you ive had 3 maniplations as well), anyways, i am having severe rash/ hives all over, itching, fatigue and severe all over body pain. My insides feel like, you know when u have burnt yourself on the oven or something like that? Im burning on the inside out. My hands, face, arms, chest are bright red most of he time. I get hives even on my palms or the soles of m feet. I am walking with a limp again, unable to control it. The pain, hives, fatigue, weakness, and all of this is getting unbearable. I know i either have an allergy to the metal or the cement. I would tell anyone who is thinking of having this surgery, to have a metal allergy test first before doing it. I am only 48 but feel like i’m 90. Please think about it and talk to as many people a you can. If i had the choice to do it all overi definately wouldn’t.

  59. Kelly on February 23rd, 2012 7:03 pm

    My fiancee had a TKR Aug., 2010. approximately 8wks later he started breaking out in a horrible rash on his back and arms. Both looked the same but his arms (top to wrist) swelled then started cracking, oozing, and bleeding. His arms looked like the texture of bark on a tree. He was given topical creams, and steroids. The rash on his arms went away after about three months but left scarring but the rash on his back clears up then come back every other month. After the arm rash cleared, he soon started getting a rash on the palm of both his hands. They too started swelling, cracking, and oozing. The rash then spread to the top of his hands. They looked so bad he became very self-conscious about it and started wearing gloves(during the summer, in Texas). The palm of his hands now look like they have been burned.
    The dermatologist prescribed steroid pills for about a year, 6-8wks of UV light treatment for his hands, many different creams, and now Cellcept-500. It’s not doing any better than the previous treatment. Fred has had the skin patch test which tested him positive for things he has never been allergic to before such as blue dyes, neosporin, epoxy, etc.
    I called his dermatologist today to request the LTT-MELISA. The doctor who performed the surgery says that he is not allergic to the titanium. I am thinking he is allergic to something that is in the replacement part.
    The precriptions are hurting us financially, along with the co-pays to see a dermatologist. The Cellcept cost almost 1100.00USD for a month supply. Also, he seems to be sleeping all the time. He doesn’t want to do some of the things he use to enjoy doing like working on cars, yard work, painting, etc.

  60. Butch on February 26th, 2012 2:25 am

    Though I have a TKA — I’ve had two Zimmer UKA that failed and now have a Stryker Marathon TKA in the same knee (which still swells and requires frequent icing) , I’m now of the opinion that some people simply shouldn’t have these put in their body, especially the younger, active and stronger patient. I think if you are younger and active, the higher the chances are that you will require a revision(s), and sometimes that may be required in just a few short years. If you remain in a Barcalounger after your surgery, you have a much better chance of a successful outcome, but of course your muscles will atrophy and in the chair you will remain. Physical therapy is a must after the surgery.
    Back to the point. I had my first UKA at the age of 47 and was in excellent shape, and what I write is from my personal experience and may not be applicable to all. But I have had many varieties of articulating surfaces that have all led to complications. With Polyethylene, I got osteolysis and developed lesions in my femur next to my implant that required bone grafts to remedy. I’m just saying these things do not always (often?) perform as they’re said to, at least from my experience of needing four arthroplasties over the course of the last decade (and again three in one knee).
    The fourth I had was a THA, and I have seen people comments here about the wondrous new Oxinium, a super-heated ziconium that becomes as a ceramic, reputed to be vastly superior to titanium, polyethylene and not as brittle ceramic on ceramic (That product is in the world of THA now, not TKA). I was told that this Oxinium was much more wear-resistant than a typical metal on metal surface, especially one like the recently recalled Depuy THA that have now been shown to release large amounts of metal ions into the tissue surrounding the hip and often entering the bloodstream, conditions your friendly doctor would call metalosis and blood poisoning, respectively. But have it I do, and I have been told all of this — every material I have been implanted with — has failed because of my alleged ‘hypersensitivity’ to the materials, or my having an allergic reaction, etc. I have been told this in each and every case, by three different doctors and in all of my arthroplasties. I say Hogwash!
    Speaking directly from my own experience, this is simply a way of their ‘passing the buck’, because these Orthos either can’t explain it or won’t. I have now developed metalosis in my new (less than three years in) Smith and Nephew Oxinium ‘wonder hip’, and I have to have it revised next month. (At least I do not have the cobalt and chromium levels of the admittedly inferior design of the metal on metal Depuy THA). But I have damaged tissue, the implant is now loose and very painful, and I am using a cane again (My upper body is stronger then my lower).
    If you know anyone who is considering any type of arthroplasty, tell them to research whatever type and/or manufacturers product their surgeon plans to install in your body. Try all alternative options before you agree to let them take out their saws, drills, hammers and chisels, because it can actually worsen your condition and lead to much more pain in all aspects of your life
    If I could do it all over I would, but I (like so many my age) truly trusted my doctors implicitly. But they don’t look at the whole person, they give no credence to viewing the human being holistically. They look only at the bones they work on, the skilled craftsmen they are who consider no other aspect of the patient’s lifestyle, body, and what type of activities they are engaged in.
    I regret not having my entire bone structure any longer, and I am on a merry go round that I can’t seem to get off of. At 58, how many more arthoplasties will I need, if I live to the 91 years my father did?
    And if you’re about to have a revision, get on the google machine and research whatever it is the doctor wants to use, and look closely at the huge body of evidence regarding the subject matter online related to its performance.
    Good luck to all of you. And most importantly, caveat emptor.

  61. robert blau on February 27th, 2012 12:58 am

    I have similar issues with my DePuy Rotating platform knee.I have finally found the lab to do the test.For your information it is;Metal Testing Laboratory Orthopedic Analysis LLC.2201 W Campbell Park Dr. Suite 211 Chicago IL.60612-4092 Ph # . You can order a test kit from them.However a M.D. will have to order the blood draw at a lab.Good luck to all.Does anyone know who manufactures the Tivanium knee?

  62. Allergive to BONE CEMENT on March 15th, 2012 2:32 am

    Please, if anyone has any suggestions email me. My name is Jessica, my mother had her knee replaced at age 52. She is having serious complications with her replacement. She is allergic to the bone cement, along with metal/cobalt/nickle etc. If anyone knows any information that can help me it would be greatly appreciated. We are looking at the West Coast, possibly other countries for a another specialist. Please. again, email me if you have any information. Thank you and Godbless!

  63. julie arafiles on March 15th, 2012 5:50 am

    labcorp does the melissa metal test. i have gone throught one year of pain and requesting a metal test was something the doctors do not acknowledge. labcorp is local in every city and sends out your blood to a malissa lab.

  64. Laura Lipscomb on March 18th, 2012 5:27 pm

    I could have wrote this entire page except I can not remember having any rashes! Two replacements, one revision!! Same problem; so much pain! constance swelling, hot then cold, can’t lift it of the floor sometimes because it gets to heavy and grabs to the point i cannot walk for more than 15 steps! I’ve had more therapy than anyone person should have to endure and nothing helps. Thank all of you! I have found a Doctor that is working so hard with me to get me some releif from this pain! I now have more information to pass on to her. GOD bless all of you.

  65. Yvonne on March 25th, 2012 8:36 pm


    I will need a TKR soon, and I suspected that I had some type of metal allergy since pierced earrings make me itch. I was told that getting the Smith & Nephew Oxinium knee would solve that problem, as it contained no nickel. But the more I researched, the more I discovered folks who had that implant and still had allergic reactions. I found a doctor who specializes in revision surgery, and who told me to get fully tested at Orthopedic Analysis in Chicago. ( He said that skin patch tests were inconclusive. The results were eye-opening. I found that I am allergic to nickel, titanium, and zirconium. Also borderline on bone cement. The Smith and Nephew Oxinium knee contains zirconium in the femoral component and titanium in the tibial component. So that would have been a disaster. Now we are exploring implants that my body will tolerate. There is no reason why surgeons do not demand this test be done on anyone planning replacement surgery. Why is it done only after problems arise? Think of the money insurance companies would save by avoiding a second revision surgery, not to mention the pain and suffering that would be prevented.

  66. Johanna B. on April 13th, 2012 9:28 pm

    April 13, 2012
    Thank you all for your personal experiences, comments on metal allergies, & various manf. of knee replacements and the symptoms you had to cope with.
    Had a complete rgt. knee replacement Apr. 2010. After 10 mos. of PT, 3X wkly. I started to have heat, swelling, ltd. motion as soon as I got back to my active life…I walk a lot. I was told it was an inflamation & given “Voltaren Gel” to use 3X day & rest which I did for 5 mos. Swelling receded a bit but I lost nearly 30 % of Flexion, to 97 degrees(bending.)
    After 1 1/2yrs. of of doing everything asked of me & every type of PT, on my 4th. visit in 7 mos.for this new problem, my surgeon, @Hosp. for Special Surgery, (the best ortho hosp. in the US,) said to me, “There’s nothing else I can do for you.” Threw up his hands & walked out. Period.
    I am way to young to be handicap & not do the basics, like walk up & down stairs w/o pain.
    Subsequently, I have found a new doc. in NYC, who has started a series of testing to gather data to determine what to do next.
    After discussion w/my PT today re: knee acute stiffness & inability to move no matter what, along w/chronic inflamation, & itchy rash that has occured out of the blue, during the past 6 mos, I now have a more rational reason for these weird symptoms….the “Cobalt” knee from Stryker. I will pursue allergy testing vigoruosly along w/the other tests which we began a few mos. ago.
    So, thank you again for putting it out there & helping me put pcs. of a v/complicated puzzle together…your points of view & what you learned are v/helpful.
    I am determine to get my life back & this will help.
    All the Best,
    Johanna B.

    PS. Metal allergy testing should absolutely be done before each surgical replacements!

  67. PhillipsC on May 20th, 2012 1:24 am

    I had tkr 2008, revision 2010 on right knee, which still hold fever off and on, swells and is still very numb on the outside. Last year in June, my left foot started to peel. It went thru a cycle, peel and heal until January. In January the peel the foot never healed. It stayed raw. The only way for me to walk is on my toes on the left foot. I went from family Dr to foot Dr to derm Dr to derm Dr. The last Derm Dr did allergic test which resulted in contact eczema to cobalt / nickel allergy. I informed the Dr about my knee and she does not think the allergy is coming from the knee. I so sorry to say I’m not walking around eating pennies and licking doorknobs. Contact eczema means that there is something that I am coming into contact more than once. If its not coming from my knee then how else. There are way too many other things to taste other than metal objects. So during my last doctors visit I got very frustrated. I let the doctor have it. This event is very very painful. I don’t feel like none of my doctor care. I have had 2 tkr and have said I’m will to do another tkr to heal my foot. The derm doctor has been out of the office last week, so i have to try to get in next week. After my frustrated last visit she said she needed to do some research. Hopefully she is researching the possible connection. I have a Ortho appt on 5/30 to talk to the doctor about the allergy out break and a 3rd revision. This outbreak is wearing my on all levels.

  68. Effie Burt on May 29th, 2012 2:32 am

    It is hard to believe that this many people can be wrong about rash after TKR. On Dec. 20, 2011, I received a Smith and Nephew Genis 2, I start getting red bumps two weeks after the knee replacement and I am still getting the spots which are now black on several places on my body. My doctors don’t believe that my knee repacement is the cause of this rash. I wish they were right but I know that they are wrong. I ask Smith & Nephew to give me the info of the metal that’s in the TKR and it took them two weeks before they would give me the info. I am going to get tested but I know that I am alleric to Nickle. I have to find a Knee replacement that does not contain nickle if there is one. Other wise I have no ideal what I am going to do. If anyone knows of a knee without nickle please e-mail me.

  69. Pam on May 31st, 2012 7:26 pm

    AESCULAP AS (alternative surface) by Columbus supposedly has no nickel.
    How do you get a LTT-MELISA test.? I went to Dr. and he gave me the paperwork to get one but Quest nor Lab Corp. do the test.

  70. Jim on June 2nd, 2012 3:13 am

    They do metal allergy testing on your blood. Go to the website and request a kit be sent to you.

  71. Marion Miller on June 7th, 2012 5:34 am

    I had severe pain and had multipe surgeries starting with alighnmrnt / lift kit / new tread Im diabetic and got a bad infection in my first knee reuiting another trip to hospital and the had to build an infectuous disease team as no drugs were working. I had the second align/lift/tread done on other leg which just had excessive blood loss. Then in 2008 I a zimmer pkr in October which did well and in December a pkr (size 2) with bad infection and home if therapy. It has been less than 4 years and I started having intense pain

    Any information on the process to step up for more surgery). Issues with device ? Issues with a physician? I had dr caborne in Louisville

  72. Effie Burt on June 10th, 2012 1:09 pm

    I submit a comments about TKR on May 29, 2012. I had a Smith and Nephew Geniss 11 TKR on Dec. 20, 2011, and rash appeared on the area around the incision of the TKR.

    I went to a dermatology and was told I had Lichen Planus,

    Ok I asked him,why would it start around the incision around the area of the TKR. No answer for that, I asked how can you tell me that I am not allergic to what is in my knee when you don’t know if I am allergic to the metal in my knee, since I am allergic to nickle, no answer for that either. I contuine to get the rash.

    At this point the rash is on my lower back, the sides of my body, my other leg and now I see new rash that has started in the back and around the TKR.

    I was given a steriod shots, I finially strongly suggested to my doctor that I need to find out if I am allergic to anything in my Knee. He said that people will think I am crazy.

    I told hiim, it is crazy when You tell me what I have a rash that know one knows how you get it. Crazy is for you to tell me that I am nor allergic to any metal in my knee and you have not even had me tested for the metal. So don’t dare call me crazy. You might hate to admit that you might not know what you are talking about.

    SO I WILL BE GOING TO Lab Core for a blood test of the 3 metals in the Smith and Nephew knee. I will report back when I receive the results.. I am also going to take a pacth test after the blood test for the cement as well.

    I hope that I am not allergic to the metal and the rash will go away and don’t come back. My doctor who replaced my knee did a great job as well as my PT and after 6 months my knee is feeling great, but when I get the rash it itch I, can’t go swimming and if you sweat you itch all over. Lichen Planus symptoms can be control but it is a unpleasant and difficult to treat but it is a stable condition.

  73. Bonnie S. Bishop on June 27th, 2012 6:15 am

    Bonnie, June 27, 2012 24:45pm

    I am scheduled to have a total knee replacement on July 10, 2012. My Dr. did do the metal allergy test and it did show I was allergic to several metals so he is to use a replacement by Smith & Nephew that supposedly has no metals. Until reading these comments I thought all was going to be well. Now I am SCARED TO DEATH!!! What about the cement problem? Dr. has not mentioned this. Have had all kind of problems with both legs for the last 14 years. I am only 67 yrs. & am so tired of not having a life. I have had lymphedema since 2004. Is there a Smith & Nephew replacement with no metal and if yes does anyone know the name? My Dr. says he uses the cement mostly in women because of osteoporsis causes the bone to be so soft & the cement holds it in place. DO NOT KNOW WHAT TO DO.7-10-12 is almost here. I will talk to Dr. This afternoon & if any one has more information please let me know. Do not think I can stand another 14 yrs. of all this pain, plus a horrible rash. Both legs are shot ,cannot walk or stand over 25 min at a time. If anyone has an IDEA or more info please help. So Glad I READ THESE COMMENTS——God Bless, Bonnie B

  74. Effie Burt on July 1st, 2012 4:29 pm

    I have had a metal blood test for the metal and components in my smith @nephew genisis 11 cement knee replacement. none of the test came back to be postive. I still wonder, why would I get a rash like I have never had before in my life surrounding the area around the TKR. I am not going to give up until I find how I got this rash.

    Bonnie , you are the only one who can make a decision about your knee replacement. I wish you well and would like to keep in touch to see how you are doing.

  75. Effie Burt on July 7th, 2012 12:58 pm

    just finding out after getting a patch test, I am allergic to the cement. I knew that I did not have lechen Planus. This rash is a look alike to lechen planus. I am now taking anibotic for 15 days. I am going to talk to my attorney general to demand that any company using implant should provide testing for all componets being placed in your body.

    Implants are like buying a house that you intend to keep for the rest of your life.

    I don’t know if this bacterial is in my blood stream or what damages it has cause after 7 months in my body to my organ. I didn’t sign up to be a doctor but I feel that I”ve had a class on Smith @ Nephew Genesis !1 knee replacement. I think eveybody should talk to their Attorney General about testing before receving an implant.
    Thank God for the doctor who finially listen to me and did the patch test for cement.

  76. Mary Gilhooley on July 26th, 2012 11:09 pm

    I am highly allergic person and need a TKR. I scheduled surgery then cancelled and had allergy blood tests which confirmed allergy to Iron which is part of the metal implant, and also allergy to to the surgical glue.

    Does anyone have any experience with this and would titanium be ok as it is only .0025 base iron? Are there different types of cement used?

  77. Effie Burt on July 28th, 2012 2:30 pm

    I had the TKR on Dec 20, 2012, I have found out that I am allergy to the surgical glue or cement that is use in the Smith @ Nephew Geniss !1 knee Replace. The knee is working well but I have black spot over the knee and black spots on other areas of my body. My doctor did do a patch test and then started giving me a flagyl med., 500 mg 3 times a day. So does that me I have an infection in my blood? He will not say that I was allergic to the glue/concert enought to cause the black spot which he said was legichen Planus. I will not stop seaching for an answer.

  78. Nadine Magar on September 6th, 2012 3:25 am

    I had my 1st tkr 6/2011 since then I have had three more surgeries total I’ve had to get removal of all parts twice cause of mrsa I’m gonna go have another knee replacement done here soon my doctor said if this one doesn’t work we’ll have to cut off my leg(he wasn’t smiling or did he say he was joking) I need help & information on different procudures I’ve been hurting for over a year, it seems to go good for 4-6 mos. and the the swelling, hotness fever come back they stick a long needle in my knee and they find pus and I’m put back in the hospital getting the tkr out a antibiotic spacer put in and they send me to a nursing home sin e 6/2011 I’ve been in one for almost 9 mos and I still need to go back and get another tkr and more nursing home for pt, each time I’m in the hospital and nursing home I’m getting iv antibiotics through a PIC line that goes to the heart so I have to worry about infections that way (changes of death if this happens) so its very difficult taking showers without getting it wet no matter how well we wrap it. I’m in dire need of information on alternatives cause I’m only 49 yrs. old to young to lose my leg. Thx

  79. Kathy Cummins on September 24th, 2012 1:58 am

    i had a TKR in July 2010. I had a terrible experience and cannot bend beyond 95. I was told prior to surgery I would be fine. After surgery, doc said I would only bend to 110. problem is when I take probiotics, Omeprazole or vitamins, my knee tightens up terribly. Has anyone ever had an arthritic reaction to a TKR? it does not happen to my right knee at all. it just goes right to my TKR.

  80. Sue on October 9th, 2012 1:15 am

    It has been 7 months since I had TKR in my right leg. They did a manipulation in May and a scope in June. I have endured 3 hours of PT everyday since May. Currently I am 10 degrees from straight and can bend to almost 90 degrees. I haven’t slept in 7 months due to pain, haven’t worked in 7 months, and spend most of my life in bed with my leg out straight to minimize swelling. I ice it all the time and have resorted to wrapping it in ice bags at night to get a couple hours of sleep. I am 57 and the original injury was 47 years ago. I had 5 surgeries prior to the replacement. When I asked about metal allergies, because I am so allergic to metal I have to cover the inside of the metal buttons on my jeans and be sure the pocket rivets do not touch my skin. My Dr blew off my inquiry. I pursued the issue and after 4 Drs I finally convinced one to order the blood test. I am still waiting the outcome.

    Sometimes I think Drs discount the complaints of pain and swelling and itching because some people’s tolerance levels are less than others. I would like to challenge any of those physicians to endure the PT I have allowed myself to be subjected to even twice. They actually get on the table and push my leg down, hold it, and then slowly release it. Their cue to let up is when the tears flow. Nothing has helped and I have a very high pain threshold. This has been 7 months if pure hell!

    Depending on the outcome of the blood test, I will opt for a revision but I want to be sure it will not occure again. Is there a non-allergenic knee made?

  81. Peggy on October 9th, 2012 11:51 am

    I had a RTKR Nov. of 2009, a Manipulation done in Jan. 2010. That was soo painful, that I woke up from the anesthia shaking in pain. The knee did not get better with P.T. 3 times a week. March 2010 the Dr. opened up my swollen, non functionl , painful knee to cut scar tissue. That was another mistake, walked with a limp, flexion 85 and ext. 12. I was tested a year later for allergies, and was Highly allergic to Nickle, which I had no idea the knee was a colbult with nickle in it. Went to another md, he replaced it with a nickle free specially made for me, and with P.T. its now ext. 0 and flexion 120 to 125. I can now walk without a limp, although sometimes doing to much it hurts and swells. Not only did I lose my job, had much pain, and fustration!!! The M.D. should be held accountable for this, because he knew I was allergic to cheap jewlery!! It should be a routine test for allergies before any implant is inserted!!! Anyone out there that wants to fight for this, so many other baby boomers dont have to go thru what many of us have!!! Its a discrace to the Medical field for this negleigince!!!

  82. concerned daughter on October 20th, 2012 2:02 pm

    My mom had a tkr Nov 2011. Because of her metal sensitivity she had a titanium Smith and Nephew.. the knee was inflamed after surgery. Weeks after, she had a rash on the implanted knee. This rash grew into black scabs which spread from the knee to her back and chest. This was later diagnosed as Lichen Plannis (sp) and dismissed as an unrelated condition o_0. I got her to dc with new open minded doctors and new round of tests. In addition to the metals in the replacement knee..she also got PATCH tests for the CEMENT that is also used with the knee. They tested both the powder and liquid components separately….she was found to be allergic to them. Her first doctor tried to make her think she was crazy for even suggesting a correlation between the tkr and the rash. She just got the results from the new Dr. yesterday and we are so relieved. There are new studies out that talk about how these rashes are allergic reactions and are being misdiagnosed and going untreated. We are planning to have the knee removed. We also learned that some forms of nickel are also inside titanium knees, bound together there is low risk of reaction, but sometimes particles can work their way loose and into the bloodstream through movement and or friction. Keep your head up and don’t stop fighting for your health. Change drs if you can. If you don’t advocate for yourself, no one will. Good luck!

  83. Pam on October 24th, 2012 10:05 pm

    Finally had blood tested at orthopedic analysis and confirmed that I am highly allergic to Nickle. What is the name of the implant that has no nickle in it? Is it from Smith and Nephew? I think they make a titanium implant, not sure? Also the AESCULAP AS (alternative surface) by Columbus is a new implant but no information on track record or reliability as I think it is new. I need an implant by years end and still not sure which is best for me? I am searching for the best implant then I will try to find a Dr. who uses that implant. Any help would be appreciated…

  84. di on November 16th, 2012 8:53 am

    Segue 17 and Stevie C….did you ever get an explanation or diagnosis for your symptoms?
    I too have an oxinium knee (5 years post op) and have had the same symptoms as yourselves for a few years now. I have undergone numerous tests and biopsies on the fluid taken from my knee and on bone and tissue samples…all have been inconclusive. MRI scans show damage to my femur and tibia around the implant (fluid filled holes and lesions) for which the ‘experts’ have no definite explanation. Initially, they thought it was an infection but they can’t isolate a bug and feel if it was infection it would have been very evident by now.
    I would really appreciate any further information you might have. Many thanks

  85. Alan on December 29th, 2012 12:56 am

    I had TKR done Nov 2010 and January of 2011 had first manipulation and for 3 months more manipulations. 9 months later lower knee done again same pain as 1st knee RIGHT after surgery
    still no bend and yes same pain. Doct put in wrong size. Cut thigh muscle and tendon screwed it to bottom of knee leg in splint for 6 weeks, No bend worked my but off and still no better, Tired of this.
    Went to another doc and guess what allergic to both the metal and Glue. Going for 3rd knee replacement, I want tis done right so i can enjoy my son.
    Please go see an allergist find out wished i would of.
    They said if you never had a reaction you won’t know till it’s in your body. Now makes sence.

  86. Vicky on January 2nd, 2013 1:00 am

    had tkr in 2008 folowed by 2 revisions! Still in agony and have found no help. While I can bend my knee, after any periods of walking, standing or sitting, results in severe swelling. Am in constant discomfort and not able to sleep well due to discomfort. Have seen 3 ortho docs in addition to the 2 who did initial surgery. Various xrays, etc show nothing. At times I’ve been made to feel as though it’s in my head or I’m just a whiner…with all the discomfort I’ve been in for 3 years now, I hardly think so! I’ve been on oral meds, patches, creams, you name it. I have gotten some temporary relief from Mobic but once I was taken off, it was back to the pain and discomfort again. I do have allergies to some metals and have rashes that will often appear upon wearing jewelry,especially costume jewelry. My primary dr. is the only one who ever mentioned possible allergy.

    I live in NJ and have been treated at one of the best facilities…Rothman Inst. but still have no answers. I feel like I’ve been thrown away. Anyone have suggestions??? I’m at wits end. Does anyone know if health insurance would cover the lymohocyte transformation blood test some have mentioned?

  87. Jean on January 17th, 2013 8:05 pm

    I have been suffering for 9 months with a similar problem, except I have no rash and no itching. I have 2 implants – right knee 2001, left knee 2007. All started with the left knee – difficulty bending – able to walk but painful. Got worse had X-Rays, blood tests, cortisone shots, demerol shot into hip to see if hip was causing the pain which was worst at night. Li burning sensation – could not stand anything touching. Dr. at a loss – could not have MRI due to implant. Had X-rays of hips – some arthritis (I am 80 so I believe this is expected) Just had MRI of lower spine to see if that is cause. Had second opinion – do not want hip replacement unless really necessary. This Dr. mentioned possible allergy to plastic friction causing a powder which could be something I might be allergic to. I am a very active 80 yr. old used to walking and dancing. Very frustrated! appreciate any comments.

  88. Virginia on January 18th, 2013 2:25 pm

    Vicki, you’re close enough to BBB, used to be at Pennsylvania Hospital but has moved now. Dr. Bob Booth is the go-to guy for knee replacements — literally wrote huge sections of the book. Having said that, you will need to stand on your head and demand the allergy blood test for metal reactions. They draw your blood and submit it to the facility in Chicago — I understand there are only two testing facilities in the country. I am on my second knee — had an allergy to the nickel in the first one and really think that I am reacting to the aluminum in the second one. You may also want to go see Dr. Norman Kovan, allergist who specializes in implant allergies. He’s working with an ortho guy by the name of Andrew Star. Both confirmed that I am allergic to my revision BUT not clear what can be done at this point. I’m relatively young and there are only so many knee replacements one can have in a lifetime. So, I’m trying everything — high doses of anti-oxidants and natural anti-inflamatories — kinda helps. Good luck. You are not crazy or weak or anything like that. Sorry for your pain. I empathize. Just keep trying and see what works for you. I’m trying an anti-depressant that helps with pain. we’ll see how that works.

  89. ColleenKendel on January 27th, 2013 12:30 am

    I have a dear friend who has now had three knee replacements. The first one got infected, which caused the necessity for a second. The second lasted 11 years and apparently wore out or something. The third one has been a nightmare. The knee swells up larger than a bowling ball – more like a beach ball. He has to continually have fluid drawn off but it fills right back up. They have had him on intravenous antibiotics even though they cannot find infection. The joint is warm to the touch. He is in constant pain.

    He had his blood drawn and sent to Chicago for the allergy testing and they said it was negative. He has no rash or itching – just the swelling and pain.

    He was prescribed steroids which only helped minimally.

    He wears a compression stocking all the time that goes from his toes to his groin.

    They are talking amputation now because they can’t figure out what is wrong. Can someone please help me point him in the right direction? There has to be a reason and an answer with so many people having these types of problems.


  90. Mark on January 27th, 2013 8:52 pm

    I had a partial RT knee replacement,that turned into a TKR. Then 2 more revisions.This was done by two different surgeons. All the while I have complained of swelling and constant pain. Multiple efusions,almost on a weekly basis,steriods and still no relief. I had asked many times could I be reacting to the metal. DRS said that it was rare. I paid for the blood test and guess what . I am sensitive to numerous metals and bone cement. First surgeon doesnt trust results ,second one does but in both cases they cant explain swelling and pain. The first surgeon a noted Boston DR has had 3 other cases and opts to fuse the joint. Both Drs think of nothing wrong with living off of pain meds. I am going in circles trying to decide where to go next. IS there a immunologist,Orthopedic Dr,rhumetologist in the Boston area that I can go to?

  91. EB on January 29th, 2013 8:37 pm

    Colleen, have they tried Levaquinn, its an antibiotics that treats mild to moderate skin and skin structure infections. Levofloxacin was approved by the FDA to treat complicated skin infections including deep wounds, surgical infected, major abscesses and infected ulcers, Streptococcus pyogenes , Proteus miravillis, Enterococcus faecalis, Methicillin-sensitives Staphylococcus aureus. I found this info on Doctor’s Guide Global Edition. under FDA Approves New Indication For Levaquin for skin infections.

    I had a Smith & Nephew Genesis 11 knee replacement on Dec, 20, 2011. Two weeks after the TKR, I started having a red rash on the knee and it felts as if my knee was on fire. The red bumps soon turn to black spots which have now spread over 75 percent of my body. I just happen to find out about Levaquin on Dec. 6,2012 and started to using it. After 3 weeks of using the Levaquin the black spots stop spreading on the inside of my arms and have also cleared up. I wish I had know this before my skin became damage as it is today.
    My doctor here at Sina Hospital in Md, was very open minded about trying the levaquin. The doctors in Miss, told me that I had a skin desease call Lichen Planus, which I have found to not be true.

    The itching all over my body is gone as well as the burning in my knee.
    I also found out after taking a Metal LLT test that I am allergic to bone cement, iron, Nickel, Cobalt alloy particles, titanium alloy particles.
    My skin on my body looks as if it have been burned and I don’t think that it will ever clear up. I am thankful that I don’t have black spots on my face and arms.

  92. Christa Davis on March 11th, 2013 12:34 am

    My mother was diagnosed with Inflammatory Myopathy. It was a very odd diagnosis since she had been extremely healthy and vibrant her entire life. Then I began doing research just like SO many people on this blog have done because she began to have pain in her knee replacement. I found notes I kept that stated she began to have hand and arm weakness AFTER her knee replacement in July 2006. In March 2006, she had a hip replacement. I checked with her original orthopedic surgeon to learn that both of her joint replacements were Cobalt-Chromium-Nickel. After many visits, we found another orthopedic surgeon that listened to my theory. I believed if the “types” of metals were revised, then her health would rebound. He agreed there was a chance of hope. He did her knee revision to a Titanium implant. Then she had a blood allergy test. She was allergic to Cobalt and Nickel metals. Her hip also began having a great deal of pain, so it was revised to Titanium. Her Inflammatory Myopathy is no longer causing her health to decline. She couldn’t pick up a glass and she’s back to driving, etc. I wrote a book telling her story with the medical sources I found in the United Kingdom. They have had an orthopedic data registry for over 30 years. The U.S. did not start one until May 2011 and it’s not up and running yet. The book is called “Steel Standing.” I wrote it to help others realize metal allergies are not SO rare. The medical facts are credible and listed in the book. Her medical case was deemed a medical breakthrough by the University of Alabama in Birmingham on Feb 17, 2012, because her Inflammatory Myopathy began reversing when she was able to “regrow” new muscle tissue. Previously, she was given NO hope except steroids which has terrible side effects. I knew new in my gut I could not give up on helping my mother find out what was wrong with her. She is a walking miracle. I do feel for each of you have any small signs to huge dilemmas especially when orthopedics are telling patients that there is no health problem associated with a metal implant. We learned the hard way. I wish you all the best.

  93. Joe Lothspeich on March 20th, 2013 3:28 pm

    MY mother had tnr 18 years ago,and has a rash and itch every since.
    What can she take or do foe it???.She will be 90

  94. Kathy Cummins on March 21st, 2013 2:00 am

    I would like to get in touch with Kelly who wrote about her fiancée on Feb. 23, 2012 who was allergic to blue dye, neosporin, epoxy, etc. I had a TKR and have had so much trouble bending it. I have had a rash on the inside of my knee, My health is failing in other areas too. I am allergic to blue dye, formaldehyde and epoxy resin. I am questioning if I am allergic to the polyethelene and cement that has methyl methcrylate in it. I was healthy before TKR. I would like to get in touch with Kelly as her fiancée has similar allergies. Medicines are affecting my knee terribly.

  95. pat petka on March 22nd, 2013 9:40 pm

    I had a tkr done in oct of 2012 and have had itching and rash all ova , like all of u i thought it was from the diff medications, took benedryl and went to urgent care cause it was driving me crazy gave me something for the itch but didnt help after reading all of your complaints i know its not just me

  96. Kathy on March 24th, 2013 11:40 pm

    I had TKR June 2011 and it has never been right. Flared up after return to work and developed HUGE hives right on the knee three nights in a row, which I took pictures of. Also developed fibromyalgia and I’m now pretty much housebound, in constant pain and unable to walk for more than 15 minutes since surgery. Surgeon has ordered titanium for revision but due to bilateral shoulder impingement and total body weakness, I don’t feel up to it and scared it might make things worse, although can’t imagine worse than what I’m dealing with now. Totally disabled and no hope for any kind of normal life again. Surgeon also feels revision will be poor again due to fibromyalgia. I believe I DEVELOPED fibromyalgia as a result of the nickel allergy that he didn’t even ask about prior to putting something into my body and sewing it up. Anybody else out there that developed fibro following TKR? Best wishes to all who are plagued with consequences you don’t deserve.

  97. Christa on March 25th, 2013 1:02 am

    Kathy, please go to my web site and read about my mother’s case of Inflammatory Myopathy. It was because of Cobalt-Chromium-Nickel. She also was very weak, could not feed herself. I began doing research. We found an orthopaedic surgeon that revised her hip and knee replacements to Titanium. She is 95 percent better. I certainly can not make any promises to how things would turn out for you, but I wrote a book about mother’s case. She is the first medical breakthrough for muscles to regrow that were dying. She’s been rebounding for two years. I wish you the best!

  98. Kathy Cummins on March 25th, 2013 4:03 pm

    Does anyone know of ortho doc who can do cement free replacement, someone who is using another product?
    Has anyone heard of docs using new techniques in place of TKR.? I heard there is research going on. It might be using your own knee fluid or cells. I wonder if anyone knows about that or anything new out there as I need another Knee replacement and am trying to figure out if I am allergic to nickel or the adhesive from the first one.
    Docs in Boston say they have heard there are great strides being made in TKR, but no one seems to know exactly what it is. My hope is cell therapy in place of TKR. It would be a big change in this big business of TKR!!! I hope someone can shed some light on this procedure. Please share if you know of any new procedures!

  99. Bruce I on April 2nd, 2013 3:24 am

    I am astonished to hear that so many people are having similar problems to what I have been experiencing for the past 5 years. Even though I was never out of pain from my bilateral TKR during 11/07, it took 3 years before my orthopedic surgeon even mentioned the possibility of a metal allergy to me. Has anyone sought legal counsel about this issue? It seems to me that physicians would be required to disclose this possibility along with all of the other possible side effects, etc. prior to surgery. I would very much like to know of any attorney’s names who are interested in pursuing cases involving this matter or what your experiences have been when you contacted one.

  100. Joe Lothspeich on April 19th, 2013 2:34 pm

    I would like to some input on my mother knee replacement. my phone number is 701-290-9995.

  101. angie rose on May 14th, 2013 5:06 am

    Had TKR Oct 2012 have been severely ill ever since Not just rashes or hives or itching I am in severe pain all the time My leg throbs, I’ve had all sorts of weird problems from blood clots to heart arythmia ( even had to have angio procedure; I’ve had shingles twice, I am extremely fatigued I am now experiencing all over joint and body pain and the depression is setting in I have now been off work for 22weeks with no pay, (self employed) so much for a simple procedure!!! I feel like I am unrecognisable as my old self has disappeared, lost a lot of weight, walk with a limp, need a cane. I cannot function properly, Pain all the time, disturbed sleep. I have now tested positive, allergic to nickel & three other metals. Knew I was allergic to all anti inflammatory drugs before op, so did surgeon, why wasn’t I tested, better still why do some people get the cheap ceramic, nickel knees while others get the titanium.
    In Canada it seems to be an age thing, you get the cheaper one when you are younger because they might have to give you a second one, all about the buck!
    I have also been told there is a minimal risk of anyone even with other metal allergies, being allergic to titanium! so why the heck don’t they just use it.
    Getting someone to take it back out is another joke, it is a high risk procedure, so be very careful before you get this done I am being told I could now loose my leg. My ortho guy started back peddling immediately I told him the allergy test was positive, before the results he was all about having to take it out if it were positive yet immediately it was, he started looking for every other excuse in the book as to what else could be causing my allergies Remember this is a foreign object inside your body, not topical, it is poisoning you from the inside out so its not as simple as a rash, what else is it actually doing?
    This changed my life completely, it actually stopped me in my tracks! I’m 55 going on 85 now yet prior to the car accident that damages this knee I worked 55-60 hours per week and loved life Now it is an effort to start my day by noon.
    BE very careful, research everything, especially the doctors! Pain might just be worth hanging on to! Its not as simple a procedure as they would have you believe.
    Check out utube video steel standing -this lady went through hell and back

  102. Jubilee on May 16th, 2013 2:38 am

    Angie rose, I am so sorry for your pain!!! Steel standing book is great too. What test did you use to find metal allergy? I have been in pain for 3 years and cannot take most meds as they cause my knee to not bend. Docs have no answers. I feel like my body is falling apart daily.
    I had patch testing but only epoxy resin and a cement showed, but a holistic person believes you can have metal and chemical sensitivities that wreak havoc. There just are not tests to prove it.
    I hope things will work out for you.

  103. Pam on May 18th, 2013 7:28 pm


  104. EMB on May 18th, 2013 8:01 pm

    Everyone, please e-mail me at I am putting a list of concerns to present to FDA about the problems after TKR. I BELIEVE that anyone who is having a problems need to report it to FDA. This is the only way we can save someone from the problems that we now have.


  105. jewel weiss on May 21st, 2013 2:14 am

    i have been dealing with a total knee replacement for two years. several severe rashes which they said was shingles but i had the vacination , stomach problems, bladder problems and two operation later i still can’t walk very well. i am in pain all the time and have yet a doctor can not help me.. i paid for the metal testing at and just found out i am allergic to nickel(quite high) and chromium and cobalt. i knew i was allergic to nickel from a patch test but didn’t show me to what degree. anyways i was on this web site and and read about this other lab company that not only did the metal testing but also did the bone cement test. i had already paid 345.00 for the melissa test but i wanted to know if i was allergic to bone cement. i paid 550.00 again for a repeat of metal testing plus bone cement testing. this test came back and i was shocked that the reading on the metal were mild. i know this can’t be true because whenever i were nickel jewelry i swelled up tremendouly and acturally get very sick. i called this company and wanted to know why i tested mild reaction. he gave me an explaination of a different style of testing. believe me this company i don’t believe . melisa labs was highly recommended.

  106. Christa on May 21st, 2013 2:59 am

    Steel Standing is the true story of my mother’s medical mystery. Most every symptom listed on this site – even the comments that were stated in 2010 – apply to my mother’s incredible metal allergies that turned toxic. is our web site. I try to help as many people as possible and several email me through our web site. I am not a clinician but I have been my mother’s caregiver for five years. She had Cobalt-Chromium-Nickel allergies then her knee and hip metals were revised to Titanium.

    I am astonished at the number of people and physicians that do not consider metal allergy testing prior to any metal implants. We are doing everything I know to share my mother’s story to warn others. WE didn’t know but we do now!

    Don’t give up!! Find doctor or orthopedic surgeon that will listen. is also a great blood allergy test. It is more defined than Ortho Analysis which uses LTT. MELISA goes beyond LTT as a basic blood allergy test. However, my mother first knee replacement was revised before the MELISA test, which proved she had a complete failed knee implant she walked on for 37 months because her original ortho surgeon would not listen. Dr. Ken Sands, Melbourne, FL was the surgeon that did ALL my mother’s revisions.

    Be informed and keep the faith!! I will try to answer any questions if I can help someone. I’m not a clinician but I did discover what was wrong with my mother when she was diagnosed with Inflammatory Myopathy BECAUSE of metal toxicity.

    ANY unrelated health issues that emerge AFTER a knee or hip replacement, most likely could be traced back to the metal in that joint.

    Blessings to all, but particularly to those that are suffering without any direction or help from physicians!

  107. Christa on May 21st, 2013 3:06 am

    To: ColleenKendel
    Regarding your friend that could lose his leg: Try the MELISA test for a second opinion. Also remember, when doing blood allergy testing, if any one is taking steroids or other pain meds, please make sure you list that or it could affect the outcome of the blood results!

    Also, ask your friend to find out what types of metals were used in his joint replacements and revisions. If it’s the same metals or even one of the metals is the same, then that could be inflaming his leg making it worse everything he gets a revision.

    Ken Sands, M.D., Melbourne, FL may be able to help. He is a superb orthopedic surgeon, sub-specialty in adult joint replacements.

  108. EMB on May 24th, 2013 2:51 pm

    Christa, I am sure your book is great but all of use need to find a way to get all of our concerns heard in a public meeting with FDA. Some people cannot afford to go to Fl or even pay for test if they do not have medical insurance.

    There are so many people with so many problems after a tkr and no one to turn to. We need to march on Washington like any other group that need to be heard. I am sure if we stood together we could make a different.

    chris please call me or e-mail me. 319-504-1047 or

  109. Andrew L Foskett on May 25th, 2013 1:18 am

    I had both knees replaced and I too suffer from hives – for over a year. I have been on 5 -6 courses of steroids and I continue to be on a double dose of Zyrtec, a double dose Xyzal, 1 doses of Doxepin and a dose of Singulair. These have worked for a while and then the hives come back even stronger. The Allergist now wants to add a dose of cyclosporine and if that does not work he wants to add a dose of Methotrexate – all of which have side effects that have to be monitored on a regular basis. I had my allergist test me for metal allergies and the test came back positive for Cobalt. My regular Doctor did a blood test and it came back showing Cobalt – not enough to be toxic but with levels that could cause hives. The Allergists all seem to want to treat the symptoms and not the cause. They will tell you, “maybe it is the cause and maybe it isn’t – we don’t know!”, so they only want to treat the symptoms. All of my research shows that the people that do suffer from a reaction to Nickel or Cobalt from the knee replacement get better once the knees are replaced with titanium knee replacements – trying to get the Doctors to come to this conclusion is the hard part. (I am not a health care professional but with what I have seen on the net points to the knee replacement as the cause. Because only 10% on 1% of people that have knee replacements have a reaction to the metal most health care professionals will follow the “book” and not even look at this as the cause. I have yet to get a Doctor to do the updated research – when I do get a Doctor to take the time to research this then maybe the will open their minds and treat the cause instead of the symptom’s. MAYBE IF ENOUGH OF US DEMAND THEY LOOK MAYBE THEY WILL LISTEN.) I lay awake at night scratching my haves and sit on my hands during the day trying not to scratch – maybe if the Doctors went through what we do they would be motivated to treat the cause.) ALF – Spokane.

  110. Christa Davis on May 30th, 2013 1:09 pm

    EMB (and anyone else with metal joint issues):

    Thanks for your feedback. I emailed you last week at the address you provided at Hotmail to discuss further. I’m not sure why you didn’t receive my email but I will try to call you.

    If I may elaborate why I reinstate “Steel Standing” the book I have written: besides the fact it’s true story filled with common sense information; how we communicated with physicians; the steps we took to keep going and not give up when turned away from doctor after doctor; what we experienced so others could be much better informed; and the list of email links for the medical resources that are clinical studies – mostly from the United Kingdom – that I accumulated in addition to news media articles and more medical information to educate the average person, written by Dr. Vera Stejskal. inventor of the MELISA test.

    “Steel Standing” is just as much a reference book as it is a true journey and how the discovery was made for others to be able to comprehend how to distinguish if they too have a metal allergy.

    I was able to connect my mother’s health issues after doing considerable research for weeks. Only when I was able to share my theory that it was the metal implants in my mother’s knee and hip, did I approach her neurologist. He did not have a clue about the “types” of metal which can destroy health muscle tissue. Her deterioration lead to Inflammatory Myopathy. He confirmed Chromium causes renal and digestive failure. Then I relayed that important fact to our orthopedic surgeon and to my mother’s other specialists plus her primary care physician.

    “Steel Standing” was written to help educate others LONG before our family was aware of so many people suffering. I decided to place in print what I knew to be true after I continued to read blog after blog of patients that had become victims. I knew the best way to share the medical discovery and what we learned was to publish the book, which I self-published 320 pages of valuable information for anyone that was not clear if they have the same or similar metal allergy issue. So, really the book was a way to place information in people’s hands. It was never to share a “story” but to share what happened so others could learn. If you don’t share what and how you experienced things, just blogging about it will not always been sufficient due to the volume of information.

    I have also had people ask me to share the name of her orthopedic revision surgeon, who is a subspecialist in adult joint replacements. Very few orthopedic surgeons are open-minded to metal allergies. Some people can afford to go anywhere to have a revision and have followed up with Dr. Sands.

    Some people can not afford the MELISA TEST if their insurance does not cover it. But health care is changing and accepting blood allergy testing in more states. Some insurance companies will pay for MELISA. More information is available at under the tab metal allergies to contact.

    However, my entire reason for sharing the book, Dr. Sands, and MELISA Labs is due to a success routes I am able to offer others based on our experience.

    Orthopedics Analysis in Chicago does the blood allergy testing, also and insurance pays. However, their test is not as defined at MELISA. But it is an alternative blood allergy test known as an LTT.

    I have been trying to contact the media (ABC, NBC, CBS, CNN, Dr. Oz, etc.) to gain exposure to this issue for months! We were able to get local coverage but I can not seem to reach regional or national attention and I have 20 years in marketing and PR.

    People are told by physicians that blood allergies are rare. I don’t believe that to be an accurate fact. The emails I receive from our web site are from people begging for help that has very similar symptoms as my mother’s. There may be countless people that have health issues that are slowly showing that no one would begin to connect with a metal allergy because it does not appear to be directly related. That is the mystery of the metal allergies and how they attach from the metal ions in the bloodstream.

    The FDA mandated that ALL manufacturers began an orthopedic data registry in May 2011. I was able to figure out my mother’s health issue linking to her metal joint replacements in spring 2009 before the 2010 DePuy debacle. However, in June 2012, the FDA met with the orthopedic mgfs, and very little had been organized or done towards orthopedic reports.

    I’ve tried contacting the FDA to no avail.

    One man stated how he wished a doctor had to go through what the patients did with metal issues – I couldn’t agree more IF that is what it takes to get their attention!! It’s very frustrating. I have devoted myself to this issue full time when I should be working for income. The books have been slow go. I wrote the book to help others – not to become a best seller. It’s hard to make ends meet. So I completely understand anyone’s tight money issues. But I will tell you in a heart beat – this issue MUST be exposed! I am very passionate about this issue. It’s too common yet very few orthopedic surgeons are understanding that this is NOT a rare issue.

    If big business with ortho mfgs is the reason this issue is being kept quiet, then that needs to be addressed. Why would ANY orthopedic manufacturer place Chromium in a joint replacement mold when Chromium causes RENAL and DIGESTIVE failure?!?! It’s a metal that is high in supply and inexpensive. Chromium should have NEVER been approved to be placed in ANY one’s body!

    Steel Standing Fact: In 42 months, my mother had 33 lithotripsies and/or basket removals for kidney stones – NOT counting kidney, bladder and urinary tract infections. She battled this major issue on top of a multitude of other health issues at the same time. YET if there had not been a timeline to show when the gradual weakness began, we would still be scratching our heads and she would be unable to do anything placed in an assisted living or nursing home.

    After the Chromium was removed from her hip and knee, she had two kidney stone procedures! I can prove it all day long and all night long that the types of metals severely affected my mother! I want to help others and it seems forming a coalition is the best route, but I don’t know that FDA is the best place to start. Doctors say metal allergies are rare. They are the experts. I respect their education but they also need to listen to their patients who PAY their income!

    I am fired up. Everyday, I email, I mail books, articles and working with an Alabama State Senator to hopefully change legislation for pre-testing paid by health insurance companies for “planned” joint replacements. But here’s another catch – this same theory applies to stents, pacemakers, metal rods, metal screws, metal anything that goes into the body.

    EMB, I am with you all the way on exposing this atrocity of human deception and/or ignorance when most people are told that knee or hip replacements are safe. Most are safe. What about those that are NOT? That’s my point. There are many health issues needing attention in this world. But this issue fell into my lap and I am not going to stop spreading our story until someone realizes this is a serious issue.

    Thank you for your time. I apologize for the lengthy feedback but it’s a very passionate subject matter for me. I almost lost my previously healthy and vibrant mother due to the types of metals in her hip and knee. Now she “coping” and able to do things for herself, but she will never be the same due to the types of metals that caused damage AND no one warned us.

  111. Christa Davis on May 30th, 2013 1:13 pm

    To Andrew:

    Base on my clinical exposure to health care and medical faculties, after a time, steroids and the other meds you are taking will have side affects. I suggest you research the meds you are being prescribed and know what you are taking and the long term affects.

    I am not a clinician! I have a BS in health anatomy and discovered my mother’s health issue from metal joint replacements.

    Her solution was joint replacements to Titanium versus Cobalt-Nickel-Chromium.

  112. Christa Davis on May 30th, 2013 1:17 pm

    There has not been a doctor in the US to do metal allergy research that I am aware of. The United Kingdom is where you will find your research!

    I wish you the best. The longer metal implants stay in your body after having a reaction, the chances of coming back stronger were much longer for my mother to rebound. I share this based on experience after her five years of surgeries and health issues.

  113. EBurt on May 30th, 2013 5:33 pm

    Andrew L Foskett, We should all demand that FDA and our Senators of your state to take a look at our health problems after a TKR. We all need to go to FDA website and voice our concerns. I would go as far as going to Washington DC as a group.

    I feel that after a TKR, Medicare, my secondary insurance or I should not have to keep paying for medical cost for a TKR.

    This is a link to our MedWatch Adverse Event Reporting Program, Instructions for filing a report are located at Please include any pertinent information from your physicians.

  114. efm on May 31st, 2013 3:48 pm

    Metal Allergy is absolutely for real in implants. offers a blood test for metal allergies that surgeons can use to diagnose this for their patients. Many Ortho surgeons are waking up to this fact and are testing for nickel allergy in patients that they cannot explain pain and problems that have no other explanation. Certain ceramic coated knee implants (such as Aesculap AS) prevent metal ion release and have helped many TKR patients. If I was having this surgery I would spend the few hundred dollars to discover if I was allergic to metal.

  115. Christa Davis on June 1st, 2013 2:10 am

    EBurt – Thanks for posting the information for MedWatch. I’m in complete agreement with you. We need national attention somehow, some way.

    To those that need help and can’t orthopedic surgeons to listen or be open minded to metal allergies, I encourage to keep searching until you find a physician that will listen to your symptoms.

  116. Kathy on June 2nd, 2013 5:31 am

    I am 10 days post-op right total knee revision after my original (nickel) knee replacement of 6/10/11. I am unbelievably optimistic at this early stage that it might just be possible after all for me to reclaim my health and resume a life I loved prior to getting the TKR in 2011. Almost from the beginning, I felt something “wasn’t right” and so made sure I followed the physical therapy rehab plan to the very best of my ability. But even that couldn’t absolve the “enemy” knee prosthesis from never allowing the tissues and eventually, the ions in my blood to break down my body to a place of total disability and loss of motivation to do anything other than just get through the day as pain-free as possible.

    After the original surgery, despite two full courses of physical therapy in addition to deep tissue massage to try to increase circulation for possible further healing (less pain always being my motivation) I was only able to walk for 30 minutes, slowly lessening to only 15 minutes, and couldn’t stand on it for more than about and hour and a half. When I tried to return to work after three months, it still had never felt right “from day one,” just as Crista Davis’s mother! And the nickel in the knee? It had only just begun! I somehow painfully made it through the next nine month and then complained again to the surgeon about the continuing extreme knee pain and stiffness with also weight gain from a sedentary life… just what a new knee needs!
    I need to stop for now, as my stamina and energy are lacking.

    I believe with every fiber of my being that the original knee with nickel content caused the metal poisoning that had been wreaking havoc with my health and well-being for two years now, including a diagnosis of fibromyalgia and huge, localized hives right on the knee cap.

    My blessing in this (even with my insistence that it be replaced with titanium) is that the surgeon AGREED to do the revision because he finally admitted he had seen me become a broken down shell of the person he first examined four years prior.

    Be strong, firm and don’t take NO for an answer if you are having the kinds of symptoms and misery that I, and obviously thousands of others have had to deal with according to this growing trend.


  117. EBurt on June 6th, 2013 12:21 pm

    I am asking anyone who would like to share their story about the medical problems after having a TKR or a revision, please e-mail me at and I will tell you more.

    I will need the info before June 09,2013. If you are willing to share your story, please e-mail me at the e-mail above or contact me at 319-504-1047.

    Thank you,
    Effie Burt

  118. Missy Kleinhans on June 6th, 2013 11:39 pm

    I had a TKR in March of 2010 and have had problems ever since. When I first started complaining of the pain and swelling I was told “it takes at least a year to heal” and my xrays showed everything looked great!! At my one year visit I again said that I have pain and swelling (I could not walk or stand for longer than 1 hour) and I was again told I was healing well (could bend and flex very well) and to give it time. At my two 1/2 year mark I went back to the doctor to again discuss the pain and swelling. He gave me a cortisone injection which did nothing at all. In October of 2012 I had a revision done where he cleaned out scar tissue and did a poly exchange. Five months later same thing lots of paiin and swelling. Had lots of blood tests, a bone scan, and did the metal allergy testing. All test showed nothing except I had a mild reaction to nickel and titanium. Now I am being told I need to learn to live with the pain and swelling!! Could a mild reaction cause problems over time??? I am so depressed as my quality of life sucks. I am in constant pain ranging from a 2 in the morning to at least an 8 by the end of the day!! Can anyone help me?!

  119. Christa Davis on June 8th, 2013 4:38 pm

    Missy Kleinhans

    Yes, a mild reaction to nickel can cause everything you have stated. It happened to my mother, Patricia Davis Harton. You can read more at She had Cobalt-Nickel-Chromium in her knee replacement and was slowly dying. She was diagnosed with Inflammatory Myopathy, and then I discovered what caused her muscles to be inflamed. Nickel and Cobalt. She had a knee revision with Titanium, and after years of rehab is finally able to live independently again and her muscle tissue that was once told would continue to deteriorate, is regrowing!

    There is hope, but please don’t let it get to the stage we did before you do something about what you’ve shared. My mother was also told “You have to live with the pain.” After 37 months of learning that she had walked on a failed prosthesis, we are voicing what we experienced. THERE IS A SOLUTION! METAL ALLERGIES ARE REAL no matter what level the allergy test reveals. In the long run, you may also experience unrelated health issues as my mother did.

    I wish you the best with your pain. Many of us are trying to get the attention of orthopedics and other specialists to educate them on TKR pain. Effie Bert is trying to get people to send their stories to her to report to FDA.

    There are more people with metal issues than the medical community is recognizing. Wishing you the best!

  120. EMB on June 9th, 2013 1:26 am

    Missy Kleinhans, could please e-mail me at or call me at 319=504-1047.

    Thank you EBurt

  121. Kathy Cummins on June 15th, 2013 1:43 am

    Are you allowed to get an email of one of the contributors? When I hit the person’s name, I get no connection.
    I am trying to get in touch with Kelly from Feb. 23, 2012 at 7:03. Her fiancée had the same medical problems after a TKR that I have.
    If the director of this site could give my email to her or give me her email, I would appreciate it tremendously. No doc knows why I have an epoxy resin allergy and other medicine allergies after TKR. Kelly’s fiancee is the only person I have read about who has same problem. I just need help! My knee has been so painful for 3 years and cement is coming apart with kneecap problems. Thank you. I am

  122. Janet Evers on June 18th, 2013 4:46 pm

    I was so glad to see that I am not the only one who has the severe pain & swelling problems with their tkr. Mine was done one year ago today & I am in much more pain than before the operation.It was doing pretty well for the first few months & then I would have episodes of terrible pain & swelling that would happen about once a week & last for about a half an hour. It has been getting worse & it happens every day & lasts over an hour & then it takes a couple of hours to feel better. I have been going back to the DR almost every month since January& complaining about the pain. He kept telling me to rest it more & give it time.I kept trying more PT & taking muscle relaxants. Nothing helped. I finally went in the office in tears & said.,”You’ve GOT to do something!!” I went in for arthroscopy & he found lots of reactive synovial tissue & cleaned it out. I thought the problem was solved but after 2 weeks it had started again. I went in yesterday & now he thinks it might be a metal allergy. They did a special blood teas that cost $550, not covered by insurance.Next week we’ll have those results & I’ll also have a bone scan. If it turns out to be an allergy I’ll have a new replacement put in. By the way, I had a TKN on my other knee 16 years ago & it is still perfect.I have great sympathy for all of you other sufferers.

  123. Efmunford on June 21st, 2013 3:04 am

    For info on a metal hypersensitive implant alternative go to:

    This company has coated primary and revision TKR implants that prevent metal ion release. Many patients are finding relief. Tell your surgeon to read the literature on this topic and wake up to the fact of nickel and metal allergy. If there is no other explanation to your pain, swelling, etc. what is the risk getting a blood test ? Is he afraid to admit he is wrong or behind the times in technology?

    I am in this business and our surgeon customers are screening patients for metal allergy and treating them with appropriate implants for this condition.

  124. EBurt on June 21st, 2013 8:44 pm

    Janet Evers, Frist let me say, I think you should see a product liability lawyer right away. Don’t let the status of limitation past which is determine by your state.

    I have been having problems every since I had my TKR in Dec/2011.
    I am getting mix reviews from doctors on the blood test and I just had a metal patch test of 60 different metals . After 72 hours I went back and the doctor said that I had some bad reactions to some of the metals but I will have to go back on Mon. 24,13 for them the final check and tell me what metals that I am allergic to
    I did have a meeting with my Senator’s sub-committee that deal with metal devices. I was told to make sure that I report any adverse reaction or any other complaint to FDA at;

    Medwatch adverse event reporting system:
    He said that he would keep up with my case and stay in contact with me.
    I’ve asked people from this site to send me their stories about their problems with knee replacement because at some point someone will listen.
    I was also told how important it is for everyone to report any problems to the FDA, because if they don’t receive complaints, they have nothing go by.

    I will report back after Mon about my metal patch test that was done at the University of Maryland, and to have a better understanding about the Metal blood test because it has a disclaimer
    On the orthopedic analysis metal LTT results that I received, it states that this test remains unclear to what degree metal hypersensitivity in general is etiologically linked to poor implant performance.

    My Orthopedic order the test but wanted me to get a metal patch test because of the disclaimer on the metal LTT .

    my email is

    I am never giving up on getting the government to look closer at implants that have change people life and not for the good. I will say this again, if we have to MARCH ON WASHINGTON, it will be worth it just so that others will not have to go through what many of us have gone through. My life have been turned up side down. Black scars are over 75% of my body and they started around my knee two weeks after the knee implant. Please report your problems to FDA..

  125. Mary Jean on July 7th, 2013 10:21 pm

    I have been an allergic person all of my life. Need a full TKR but cancelled 2X after reading this web site. Not one Dr. asked to test me after I revealed my allergic history. Finally one nurse at a major hosp in Phila. asked me about my allergies and told me to get tested. My test from Metal LLT Analyis at in Chicago found I was allergic to monomer bone cement and also Iron which is the base metal in most knee implants. It is much too risky for me to do any implant as glue is needed in the kind of implant I need w/o iron….so I will just have to live with this situation. I wound up like this after a Dr. told me I needed orthoscopy surgery after I had PT. I felt great after PT but unfortunately I listened to the doctor instead…and regreted the surgery and pain it caused ever since! He took out my front miniscus which left me in constant pain. Get Tested Before Surgery!
    Doctors only get paid if they do surgery//not patient testing~

  126. Kathy Cummins on July 12th, 2013 4:02 pm

    I saw an article on Internet about DuPuy knee implant cement failing. The cement is called Gentamicin cement and has an antibiotic in it that is loosening the cement. The Burg Simpson Ohio Team is working on this. Their number is 1-800-713-9340. The law firm in Ohio has several medical journal articles that support that fact. They have 3 cases so far that all have the same problem. I had that cement and never was told I had an antibiotic. I am highly allergic to antibiotics so I was a little upset at that fact. My cement is loosening and I need a new TKR soon. he doc said it was very unusual after 2 and a half years. I wonder if other cements have things in it that doctors never reveal. I had a patch test and they did not test for that antibiotic as far as I know from the results. I hope this can help somone else. It is just the beginning, but they have evidence to support what is happening to these implants.

  127. Laura Lipscomb on July 20th, 2013 3:11 am

    Hi. I’m back again. I wrote about my x-3 replacements on 03/18/2012. I have since had the 4th TKR on 04/19/2013. I can tell you that I don’t have the pain I was having. I am praying that this time, the Dr. got it right. I still have stiffness and some soreness, but nothing like what I was going through! I need the other knee done, but I must wait for awhile because this one is a long way from being healed. I encouage all of you who’s going through with bad knee replacement to seek out a doctor that’s willing to listen to you. I was pushed from one Dr. to another. I found Dr. Alvin Ong thru this website and and just doing a lot of reading and research. As many Drs. as I saw at different Rothman Institutes, how is it that this one Dr. knew about the metel and the cement? Maybe Drs. don’t share information!! I will return to Dr. Ong at the Rothman Institue in Egg Harbor, NJ. There IS help for us! GOD bless each one of you.

  128. Kathy Cummins on July 22nd, 2013 12:23 pm

    Laura, thank you for the info on Dr. Ong. Did you have trouble with cement and metal? Would you mind sharing how they found right cement for you if that was the problem? Were you also allergic to a metal? What type replacement did Dr. Ong use that finally worked?
    Thank you for any info you can pass along.

  129. Dena on July 24th, 2013 12:14 pm

    I had total knee replacement on my left knee in January. I am 51 years old and an ex runner.. I also had Aortic Valve Replacement 7 years ago this month followed by a stroke..
    I’m used to being tough, but this has been a mutha! My knee blew up like a balloon 4 days after surgery and developed a bubble on the left outside of my knee. Then another bubble on top right side. Both eventually popped to leave open skin that was equivalent to a 3-4 degree burn. I have pictures that will turn your stomach.
    I do not have range of motion in my knee due to the amount of wound care I have been receiving all these months, can’t walk properly knee is swollen all the time and bruised all the time.. hot all the time and wakes me up, I still have to sleep with a pillow underneath it to keep it propped up.. I could go on and on. I cannot drive myself because I need to keep it elevated.. What is going on with my knee?
    My Doctor says it just takes time….

  130. Kathy Cummins on July 30th, 2013 10:50 pm

    July 30: Is there a chance my post of July 22 will be posted so I can find out info from previous contributor? Did I do something wrong that might be holding it up from posting? Please advise. Thanks for your help.

  131. Yvonne on August 9th, 2013 2:51 am

    For those of you who are allergic to metals and bone cement . I had a custom cementless ceramic implant done in February and have no problems at all. I was tested prior to surgery and am allergic to 3 metals. Dr. Leo Whiteside in St, Louis specializes in revisions and so knows what causes failures and how to avoid them. Do not know why everyone does not use cementless ceramic. And why don’t all doctors know about allergies??

  132. Christa Davis on August 9th, 2013 5:37 am

    This is response to Dena:

    Your question: “What is going on with my knee?” Your ortho’s answer: “It just takes time.”

    My mother was allergic to the types of metals in her knee replacement and hip replacement. For 33 months she was told by her ortho “it takes time for a knee replacement to heal properly. When I discovered that my mother’s knee replacement was creating serious metal allergies when induced “inflammatory myopathy” and was able to clinically prove the medical connection from orthopaedic journals in the United Kingdom, I began searching for another orthopaedic surgeon when her health began failing. She was a healthy 68 year old woman with no health previous health issues.

    After going to several ortho surgeons, we finally found one that understood my theory and the clinical studies that stated certain types of metals that make the joint devices have a high failure rate.

    After my mother’s knee revision surgery, Dr. Ken Sands came into the family room. He said, “It was a failed prosthesis never adhering to her bone or muscle. The top part of her knee replacement fell out into my hands. The bottom part easily pulled out.

    After her hip revision was changed from the same types of metals, my mother’s muscle tissue began to regrow. It case has been deemed a medical breakthrough by the University of Alabama Medical Center in Birmingham by her neurologist.

    I urge you to find a orthopaedic surgeon that will listen and believe metal allergies DO exist!! It sounds as if you need a knee revision as soon as possible so your health is not attacked in other areas by metallic ions released throughout your bloodstream.

    You can also have a blood test to see what types of metals you are allergic to which is called a LTT. However, there is a more refined blood test call There is also a great deal of support information on their web site.

    I wrote my mother’s story and currently revising it for publication. There are so many people that do not have a clue the types of metals that are in their bodies and what damage some metals can do.

    Don’t give up hope and keep searching until you find a physician that believes metal allergies DO exist. Most physicians I have spoke with, do not for whatever reason.

    I wish you the best!

  133. Kathy Cummins on August 9th, 2013 10:38 pm

    Dena, I had swelling for a year and a knee that would not bend beyond 95 for 3 years as well as a rash on inside of implant. I suffered terribly only to find cement is falling apart. I would suggest large Patch test and Melissa blood test. My doc told me same thing. Time and walking would get me to 115 and it never happened. I had to quit my job. go to another ortho or two for another opinion. There is a lot of talk out there about allergy and sensitivity, but orthos do not want to reveal it. It is a big business. I went to a specialist allergist who specializes in metal allergies and Patch testing. His test was more intense than regular allergist.

  134. E.Burt on August 12th, 2013 12:39 pm

    I believe that everyone one this site should get together and go to D,C,,.
    Until we bring all of this info to the table where the right people can hear us, we will always just have a site to post all of the bad things that went wrong with our knee replacement. When a knee replacement go bad…people lives are turn upside down. If you don’t have good insurance after the knee replacement you can’t not get the medical attention that’s needed. The manufactory of the knee replacement will not take care of you unless you have a knee revisions. Legally if you can’t get a doctor who believe that you need a knee replacement you can’t do anything. After 2 1/2 , I still have rash breaking out around the knee implant. The rash that started over the knee two weeks after the replacement spread all over my body and doctors did not know what to do. I read that the FDA had approved Levenqinn an antibiotic for unknown skin infection which stop the spread of the rash. I still continue to have some rash on my knee but nothing bad as it was. I can not keep taking the antibiotic so I will have to have a revisions I have gone to D.C. but one person’s problems is just one problems. If you have not made a complaint to FDA, you need to as soon as possible.

  135. Laura Lipscomb on August 19th, 2013 1:33 am

    Sorry Kathy. I am waiting for the hospital’s summary. I’m just so thankful that this time, I can walk, even do a little jugging! And yes, I am allergic to some metal. I have the lab report from the blood work that the Dr. ordered.

    I am not really sure what cement was used yet. I will let you know as soon as I get the report.

  136. Kathy StJohn on August 24th, 2013 5:49 pm

    This is a follow-up to a posting not too long after my surgeon agreed to do a total right knee revision after the first one “failed.” Even though to this day he will not admit that my allergy to the nickel in the original prosthesis not only caused the replacement to “fail,” which entailed even worse, ongoing pain that what I had prior to surgery! And to top it all off, about a year and a half after surgery I was diagnosed with fibromyalgia… that has proven to be even more debilitating than the knee(s), since my left knee has needed replacing for years now too but I need more time to heal from this one finally being “right” and healing beautifully at three months post-op. My range of motion was 125 when I stopped physical therapy and I’m sure it’s over 130 at this point because I have always been the most compliant patient you will find… I WANT my pieces/parts back in working order and at least LESS painful than they were prior to surgery and don’t think that’s too much to ask! And even though my surgeon won’t admit that it was, in fact the metal allergy that kept my body from “accepting it” at least he did as I asked and agreed to take it out even if he found NOTHING WRONG, which I pretty much knew would be the case because “technically, i.e., surgically, there WAS nothing wrong. However, from a rheumatologic standpoint it was obvious that the implant was systemically poisoning my body to the point that enough metal ions sluffed off into my bloodstream after over a year of being a VERY active Medical Assistant and eventually caused me to be unable to even continue working. I kept getting weaker by the day and more exhausted and actually feared I had cancer of some sort but had that thing we call “women’s intuition” telling me it had to do with the knee that I was by this time, very “mad” at. Chronic pain makes one VERY grouchy and I feel SO badly for all of you who continue to suffer. PLEASE make sure to be your own advocate and fight for your health and well-being… it is your LEGAL RIGHT. My health insurance is an HMO so I knew I would have an uphill battle so if I can get the job done, SO CAN YOU!!! Best wishes to all those who still suffer and can’t even get a full night’s sleep to help you get through your long, painful days. I truly have walked a mile in your shoes and know there is HOPE for you too!!!

  137. Kathy Cummins on September 2nd, 2013 11:09 pm

    I went to 2 well known orthos in Boston who told me no one in America does ceramic cementless knee implants. It is unheard of. I will keep searching. Does anyone know if the actual implant or the cement like methacrylate material is related to epoxy resin? I saw the word polymer and wondered the same thing. I find it so discouraging when 6 orthos cannot answer what materials are used in these implants they use. Does anyone know about a connection with epoxy resin or similar materials in knee implants? I have a terrible problem being able to take medicines and vitamins since this implant and all the docs say is they have never heard of that. It is so frustrating!!!Does anyone have any suggestions?

  138. Missy Kleinhans on September 5th, 2013 1:26 am

    I had a TKR in March 2010. Due to constant pain and swelling even after two years, I had revision surgery in October 2012. I am still having terrible pain and swelling almost a year later with no explanation. I had the allergy blood test done ($550 at my own expense) and had a mild reaction to nickel. After being told by ny surgeon there was nothing more he could do for me I went to see an allergist to see what they thought about my reaction to nickel and they suggested I have a skin patch test done. This test showed I am very allergic to nickel and was advised to have the implant removed and replaced with one without nickel. So, back I go to see my doctor and he tells me that they don’t rely on the skin patch test as it is not reliable (that is the same thing the allergist said about the blood test!) and he does not believe my issue is caused by a nickel allergy. He said the surgery to remove and replace the implant is 10 times worse than the original surgery, the he paused and said “and you are too heavy to have that surgery”. He suggested I have gastric by pass surgery first!! Yes, I am overweight but have weighed the same since before becoming his patient!! I wasn’t too fat for the other two surgeries he did!! He said if I lost 80lbs he would consider doing the surgery. Any idea how long it would take to safely lose that much weight without exercies as I can hardly stand let alone exercise!! And he does not promise he will do the surgery after the weight loss!! I have tried to find a new doctor but after reading my record two doctors have passed on taking me on as a patient. What do I do next???

  139. Mary Jean on September 12th, 2013 4:53 pm

    I need a TKR & I am allergic to iron, which is present in most knee replacements and also the glue. Even though I show allergy to the glue the doctor I have said he did not think it would be a problem. I was told I need to use the glue due to my age (68) because of Osteopina and I need the smith & nephew titanium knee. The Smith and Nephew knee does not have an option to be cementless. Is there any advice from anyone out there as to how to handle this knee surgery?. Has anyone used the cementless knee successfully and been older? I did have the LTT Analysis in Chicago.
    I understand the regular implant cobalt/ chrominum is about .25% Iron. My test show a higher reaction to the glue than the iron. I feel between a rock and a hard place, but I do not want to loose my leg or life over this. I have been severely allergic to many things over my lifetime but I am still active and own my own business.
    Hoping to hear a solution…thanks! Mary Jean

  140. Christa Davis on September 16th, 2013 4:16 am

    This is to Kathy St. John, August 24th and Other TKR patients:

    Please do NOT give up Hope!

    It has been proven as a medical breakthrough in my mother’s case that after the types of metals which you are allergic are revised – your health can rebound!!! The medical case was deemed by her neurologist at the University of Alabama in Birmingham AFTER the types of metals – not the device – were revised. She had been given NO hope. Her muscle tissue began to regrow! She was previously diagnosed with Inflammatory Myopathy after a hip and knee replacement of Cobalt, Chromium, and Nickel. I had a gut feeling it was the replacements. She was 68 years old and never had a major health issue, active and vibrant. My mother has the same symptoms as Kathy St. John described in her post about this one. Physicians didn’t have a clue, neurologists or orthopaedic surgeons. I had worked in health care communications privy to clinical and non-clinical environments for over 15 years. I knew there could be more done but no one was willing to take the time to figure it out because my mother’s medical case wasn’t “normal.” Again – once the types of metals were revised, my mother’s health began rebounding!! Her neurologist had never seen muscle tissue regrow after the types of metals were revised. However, the scientific findings I researched were from the United Kingdom, not the US! The US physicians appear very skeptical. Be your own advocate. Do your homework. Chromium causes renal and digestive failure EVEN if your test does not show you are allergic to it! For five years, my mother had to go through quite a journey. I wrote a book about her story – Steel Standing: Surviving Metal Allergies. Go to our web site to read more about her story. Please help us spread the word and get the media involved! I have tried. FDA is not listening. They take your complaints but nothing else is being done. FDA does NOT inspect the metal implants. Also, the longer you keep the metal in your body and you know it does not agree with your body… the longer it takes to rebound and regain your health if you can get back to 100 percent. My mother is 95 percent. She was at 30 percent quality of living. Keep asking questions! Keep going until you find your answers. That’s exactly what we had to do. I would greatly appreciate your support. I wrote the book to share what happened to her to warn others. We were not warned! I wish each of that are suffering – tremendous peace, comfort and solutions!
    Christa C. Davis, Daughter and Author of Steel Standing

  141. Mary Jean on October 2nd, 2013 2:06 pm

    There is a blog from Concerned Daughter Oct. 20, 2012 whose mom was allergic to the Smith & Nephew knee implant and was going to get a revision. How did that work out and what type of Knee Replacement did you get? Mary Jean

  142. t.b on October 9th, 2013 2:28 pm

    It has not worked out. My mother was told that she could try a Depuy Knee implant and it doesn’t work they would have to give her a knee that you cannot ever bend. She is looking at other options. The rash that had covered her body, only healed after taking 14 days of levequinn. It was as if she had a skin infection after the knee implant. We wonder would had happen if she had started taking the levequin when she first start getting the rash. My Mom found info about levequinn on the FDA page, she had the medication which she had used for an infection and she started using the levequinn on her own after the rash had started spreading on her face. After three days of taking the levequinn the spots started to heal. She told the doctors in MD and they gave her more for 14 days. Doctor have stated that you can’t keep taking antibiotic. But after stop taking the antibiotic the rash has appeared on her knee again and is spreading. She will be going to see a doctor in St. Louis on the 21 of Oct. She still have pain in her knee as if she never had a knee implant.

  143. Bytha REICHLER on November 8th, 2013 1:20 pm

    In 2008 I had a tk replacement, I was in so much pain, unbelievable, I took a metal reaction blood test and was off the charts with nichol reactions, just had it replaced with ceramic/titanium in april2013 and still extreme pain, warmth and even bruising from the pain! My allergy to metal test positive for titanium but wasn’t as high as nichol. The concentrated level must be higher because the only relief I get is Percocet 7.5. Mg. I hope this helps someone out there, because it has been very chronic and disabling!

  144. Missy Kleinhans on November 9th, 2013 12:48 pm

    I had my TKR in March 2010 and then a revision in2012 due to constant pain and swelling. Eight months later things were still the same so my doctor had me get tested for metal allergies and I had a slight reaction to nickel which he said was not enough to cause any problems. I was basically told I would have to learn to live with my problems. I went to my family doctor and she sent me to an allergist who did a skin patch test which showed I was highly allergic to nickel and she said the replacement should come out. I took this to my knee doctor and he said NO, he does not go by skin patch tests as they are not reliable. He said he could not do another surgery because I am too heavy (I am the same weight I was the other two surgeries 5’1″ 220lbs) and asked if I would consider gastric bypass surgery as he feels my weight is what is causing my knee issues. I left his office devastated! I went back to my family doctor and she suggested we try treating the nickel allergy with steroids and another allergy medicine (she also put me on a diet to help me lose some weight) and within a week I was pain free and the swelling in my knee has gone down to almost nothing!! I can’t weight to go back to my knee doctor and see what he thinks about these results. Obviously it is the nickel that is causing my issues and it took a family doctor to figure it out!!

  145. Pam on November 9th, 2013 6:46 pm

    I also had metal allergy test at
    The results, highly reactive to nickel and mild reaction to vanadium.
    I’m finally going to have the surgery soon. The Smith and Nephew Oxinium (oxidized zirconium) implant has no nickel. Problem is the tibial base plate has 4% vanadium, so Dr. is going to use an all poly tibial base plate with the oxinium femoral component .

  146. Fmunford on November 9th, 2013 10:55 pm

    There is a ceramic coated knee from a company called Aesculap. The knee implant is called AS Columbus and AS Columbus Revision and AS Vega. AS stands for alternative surface. The 7-layer zirconium nitride AS coating prevents metal ion release into the bloodstream. Several surgeons here in Houston are using this and metal allergy patients are having great results. Go to for more information.

  147. Jim on November 13th, 2013 12:26 am

    Here’s an update on my issues. Had a TKR in 2010. Revision in 2011 based on blood work showing I was allergic to nickel. Still having problems (swelling and pain after 2 years) had another blood test and this came back that I am not allergic to nickel!!! My 3rd opinion doc wanted a CT scan and now he determined the revision is 10 degrees out of alignment and feels that is what is causing the inflammation and swelling. Waiting for workers comp approval and will be heading in for 3rd times the charm hopefully.

  148. Edward on November 20th, 2013 9:24 pm

    I am 50 years old have been dealing with knee problems for 12 years and was ready to make my appointment for tnr. Before making the appointment I asked my doctor about allergies to metal and the effects on my body. I told him I cannot wear any metal that is not gold. He told me he has never had this brought up in his 20 years of joint replacement. He said to be safe lets get a metal allergy test first, but said I needed a “blood test” to accurately test for metal allergies as the skin test would not tell us if it would effect the inside of my body. My test came back that I had a reaction to nickel,titanium,metal alloys and the bone cement. When I took these results to my new surgeon (my old surgeon left the country to practice in his home country) he said he doesn’t believe it will do me any harm and is “unwilling” to even look at the facts. He said that 60% of surgeons believe the allergies will have no effect on the body and 40% believe it will. I said “are you not a medical professional, you have the facts right in front of you” and he replied “you do not know if the lab did the test right”. So I walked out of his office. I am now getting a second opinion from an allergist and will see what he says. All I want to say is JUST THINK HOW MUCH MONEY THESE SURGEONS WILL LOSE IF WE CANNOT GET KNEE OR HIP REPLACEMENTS. GET A BLOOD TEST TO CHECK IF TOU HAVE METAL ALLERGIES AND NOT BY YOUR SURGEON. THEY HAVE TOO MUCH TO LOSE. I went through ORTHOPEDIC ANALYSIS in CHICAGO (313)733-7121 TO GET MY TEST KIT. Then went to my local hospital a get blood drawn and sent it back to them. And the reason most doctors dont do the test is either they dont know or maybe the price. ($500) Or maybe they do know and dont want you to know.

  149. Knee Replacement Complications Overview : on November 21st, 2013 11:34 pm

    […] A small number of patients may experience an allergic reaction or hypersensitivity to the metallic elements in the implants. A more detailed explanation of this complication can be found our article on this topic. […]

  150. Jim on November 22nd, 2013 3:18 am

    I’ve had blood work tested by Orthopedic Analysis twice due to possible allergic reactions. The test results came back different both times. Just an FYI that’s why my current doctor doesn’t put much faith in the results,

  151. Christa Davis on November 22nd, 2013 6:12 am

    This is a reply to Edward, and any one else that has just learned of metal allergy blood testing for metal implants – My Mom experienced several set backs due to the types of metals in her knee and hip. But that was not the worst, which was bad enough. The allergies became toxic and began to destroy her muscle tissues in her upper body. She had been a pianist since age 4. Her story and the recovery process has been deemed a medical breakthrough by the University of Alabama at Birmingham Medical Center. I hope you’ll visit our site to learn more. The doctor that returned to his country was so accurate about patch testing. I have my ideas why ortho surgeons are blatantly turning away from learning the truth about metal implants, but the metal allergy testing you had done was true and credible. Please keep your determination focused and keep the hope! I’m doing everything I can to warn others so NO ONE has to go through what I witnessed with my Mom, who is currently 95 percent improved. She should be 100 percent and never suffered needlessly. Did anyone tell you that Chromium causes renal and digestive failure even if you are not allergic to Chromium. Check the facts. It’s true and horrid to think this metal is used as an alloy in metal implants and not just for joint replacements. My best to you. ChristaCDavisataoldotcom.

  152. Christa Davis on November 23rd, 2013 6:01 am

    When having your blood allergy test for metals, there can be other factors which can alter the results such as if you are steroids or taking antibiotics, etc. The MELISA test is credible in certified labs. There is a lab in Wisconsin that offers the MELISA blood allergy test and the representatives are more helpful than the experiences patients write to me about Orthopedic Analysis. If you go to my web site, you can see a sample of a MELISA test. Remember a blood allergy test can render different results based on meds, etc. Dr. Vera Stejskal’s web site at MELISA has several informative articles.

  153. Robert Blau on November 28th, 2013 10:10 pm

    I have been dealing with an allergic reaction to the DePuy rotating platform knee since January 19,2011. The LTT test Verified both an allergic reaction to the bone cement and metals. I likewise have sought multiple medical opinions which have largely fallen on deaf ears.The orthopedist in Chicago who was associated with the LTT test told me my body would encapsulate the knee and I would be fine. I’m still waiting. I have found some relief with doxycycline prescribed by my third dermatologist.Ialso take Resveratrol which when I started seemed to help a lot.the rash /hives seem to just move and centralize in one area at a time.previously I itched all over. Like now it’s my left bicep and forearm and has been for weeks.I agree the FDA needs to be involved .likewise the orthopedist need to make allergy testing with the LTT test or melisa the standard of care.I also just had a major reaction to a drug/contrast called definity.i received in a routine stress echo test. Terrible reaction.I share this so none of you are administered this contrast without some per screening. I also found some help from application of corn huskers lotion.

  154. Yvonne on December 10th, 2013 7:00 pm

    Dr. Leo Whiteside in St. Louis Missouri does ceramic cementless knee implants and is well aware of metal allergies.
    He also specializes in revisions . I am highly allergic to nickel and 2 other metals and have had NO problems with his implant.

  155. Effie Burt on December 12th, 2013 4:09 pm

    Yvonne, I am going to be getting a revision and Dr. Leo Whiteside will be do the surgery. When did you have your revision? How long did it take to get the revision and how long was your recovery?

  156. Kathy on December 15th, 2013 7:09 pm

    Missy K – DO NOT GIVE UP!!! My surgeon finally agreed to replace the prosthesis with nickel in it with one with titanium and it has been as different as night and day! He never believed nickel was the cause but couldn’t find anything medically or scientifically to explain the continuing pain, swelling and disability, even after a nuclear bone scan showed nothing wrong! The revision surgery was no bigger a deal than the original surgery and if anything, was a bit easier in that I knew what to expect this time and was SO pleased with the almost immediate noticeable difference in my progress and the much faster rate of healing that was allowed to take place once the allergen was removed. The surgeon has since conceded that I knew my body best because the allergy to nickel was exactly what was ailing me and my recovery. It’s like the whole joint remains so “angry” that it was hurting to begin with and then you go and sew in something that makes it feel even worse so it retaliates and in my opinion ultimately resulted in the development of fibromyalgia that I still have hope will disappear eventually as the metal ions that were released into my bloodstream those two years between surgeries get filtered out over time.
    I hope this helps those who still suffer keep the faith that there ARE surgeons out there who will listen. Mine belongs to Kaiser so unless you are a member in Southern California, he can’t help you, unfortunately. Still, try to remain hopeful because word is at long last getting out and the medical profession is finally being forced to listen so be proactive on your part or things will never change!
    Best of luck to all who are in chronic, daily pain of any kind. Bless you.

  157. Yvonne on January 5th, 2014 7:00 pm

    Effie -

    I had my ceramic knee done by Dr. Whiteside in in February 2013. The surgery was no different than any typical TKR and I was driving and walking normally in about 4 weeks. Full recovery was about 3 months meaning I did not even think about it anymore. Dr. Whiteside is great!

  158. Nadine C Magar on February 25th, 2014 12:40 pm

    I’ve had 3 TKR and 1 severe cleaning after each surgery I’ve had to stay in a Nursing Home for 6 weeks for IV Antibiotics and to this date I go to a Infelicitous Diseased Spec. every month to get blood work done to make sure the infection is not back the last replacement it was 2 weeks after this test that I was back in the hospital with another bad infection and they had to take it out again the doctor who did my replacement said 1 more time we’re going to have to cut it off. I’m going to get a 2 opinion at UW. But from day 1 both my mom and I asked about allergic reaction, and after each surgery’s (7 total) I asked if it was due to allergic reactions only once did the doctor say anything about testing and to this day (going on 8 months) he hasn’t set up the test I finally asked my PCP about setting it up. I’m only 51 years old and I’ve gone through 2 1/2 years of torture, the doctor used the same material each time and the infections I had were never the same I’ve had different infections a 1st for him he said

  159. Ward on February 25th, 2014 9:58 pm

    13 AUG 2013 My spouse had TKR on the right knee. From day one she had extreme pain and swelling of the leg also unable to sleep without a pillow between her legs, cannot walk without pain, not able to bend her leg to far has hard time going up and down stairs. It has now been over 6 months since TKR operation. Doctors seemed puzzled about both the pain and the swelling, since they have already given her the strongest pain medicine they can find they are wondering what to do next. I have down loaded all 157 files on this website and am going to present it to all the Doctors at her next appointment maybe this will add some weight to this allergy problem that some doctors don’t believe exist. Will post update after next appointment.

  160. clyde d morris on March 13th, 2014 8:18 pm

    i had tkr and have a rash all over my body that itches like crazy it will not go away wondering if anyone else had the same problem to knee replaced 8-24-12

  161. Effie Burt on March 17th, 2014 1:33 am

    Clyde MORRIS, I had a TKR on DEC. 20, 20100, One month after the TKR, a red rash that turn into black spots started around the incision of the TKR, I was told I had a skin rash ‘licken planus, I later found out that I am allergic to bone cement, which is in the Smith and Nephew knee replacement. I also found out that LEAQUIN 500 stopped the rash after the black spots had almost spread over 75% of my body. Don’t let the doctors dismiss you. I also went to Dr. Leo Whitside in Missouri to confirm my allergic to bone cement. I am planning on a revision soon. Blessing

  162. Viv on March 17th, 2014 11:01 pm

    I had a TKR in December 2010 and everything went down hill from there. I started itching about five months later and didn’t stop until I had that TKR removed. ( I had massive infection that of course the not lovely orthopaedic surgeon will take no responsibility for ) After having the surgery to remove the TKR I woke up to no itching for the first time in three years. I have since had another prosthesis put in and sad to say the itching has started again but no where near as bad as before.

  163. Jeff on March 29th, 2014 9:45 pm

    TKR in 2005. Revision in 2007. Terrible knee pain. Feels overstuffed. Hurts all the time as much in resting mode as active mode. Pain Management Plan of hydrocodone and lyrica. Lyrica helps but life altering pain. Can work but in much pain and at times very unproductive and cannot think clearly (need to think clearly). Muscle pain now everywhere. Am afraid that I will not be able to get out of bed to get to work is not far off. No rashes, but pain. I want to rip my knee out and pick another off the shelf and install it, like replacing a worn our tire. Constant fatigue. You know something is really wrong. Going 4/7/14 to knee metal allergy expert in Chicago. Have tested reactive to nickel, gold and cortisone. Nickel allergy confirmed by LTT test, patch test confirms gold an cortisone allergy.

  164. Kathy Cummins on March 30th, 2014 11:49 pm

    Jeff, I am so sorry for your trouble. I have had 4 docs tell me cement is falling out and 2 who say I do not have trouble. It is frustrating. My knee has been in pain since it went in. My muscles really hurt and it feels like my leg is dragging. Medicines affect my knee and won’t let it bend. The docs do not have an answer for me, but I wanted you to know I think I am experiencing similar physical feelings. They look at me like I am crazy. good luck. Please respond with your results. I hope you get relief. I know what it feels like wanting to rip your knee out!!!

  165. Clyde d. Morris on June 3rd, 2014 6:48 pm

    I had total knee replacement on 8-16 2012 and two weeks after a rash has covered my whole body and it itches bad think it from the nickel in the knee any one else e-mail me.

  166. Effie Burt on June 6th, 2014 7:30 am

    Clyde, I had the same problems two weeks after my Smith and Nephew knee replacement. I read about Levequin 750 mg a day for 14 days and that stopped the black spots from spreading and predesone stopped the itches

  167. Phyllis Morris on June 29th, 2014 3:19 pm

    I am allergic to nickel too. I have needed a TKR for years. Had metal testing done & got the itchy rash all over that lasted for 2 months. I have always been sensitive to nickel. I don’t know what to do.
    Both my knees need to be done, especially my right knee – my leg is bowing out. I live in Maine & 5-6 doctors over the years have not wanted to do a TKR on me because of my metal reactions.
    Is there a Doctor in Bangor Maine that could help me? I live an hour from there. Portland is too far away for me because I live far north in the Downeast region.

  168. VivMehrtens on July 8th, 2014 5:31 am

    Phyllis get on to face book and have a look at the tkr replacement sites as there a lot of people from USA that will be able to help you. Good luck

  169. Missy Kleinhans on July 8th, 2014 1:41 pm

    I had my first TKR in March of 2010. I had a revision done in October of 2012 because I was still having pain and swelling. After the revision my doctor said my implant was fine, secure, and all he did was clean up some arthritis. He said after PT I should be fine…I was not. In 2013 I still was having pain and swelling. My doctor suggested I get tested for metal allergies. My insurance would not cover this $550 test but I had it anyhow as I thought it would be the answer to my problem. It came back with a “mild” reaction to nickel. My doctor said a “mild” reaction was the same as no reaction. He than decided all my problems were due to my weight and suggested I have gastric bypass surgery!! Yes, I am overweight but not enough to have gastric bypass surgery!! In desperation I went to my family doctor to see if she could help me lose weight she suggested I see an allergist and have the skin patch test done. I did this and it came back that I am highly allergic to nickel. I took these results to my ortho doctor and he said they do not go by skin patch testing and I still needed to lose weight to solve my problem. I went back to my family doctor and she put me on steroids and an antihistomine for the allergy and within 10 days the pain and swelling in my knee was GONE!! I waited 3 months just to make sure it wasn’t a fluke and went back to my ortho doctor and told him what had happened and he was shocked. I had been pain free and swelling free for over 3 months just by being treated for the nickel allergy. He then believed I had a nickel allergy and in March of 2014 he removed my implant that had nickel and put in one without nickel and I am recovering very well. I am sure I will have a full recovery and have my life back when this is all over!!! I wish my doctor had listened to me and I had not suffered for all this time but at least it will be over in the next few months!

  170. Shirley Cox on July 22nd, 2014 1:31 am

    I have a nickel allergy (found by my dermatologist) I had a tkr in November 2013. Fortunately, my doctor was made aware of this allergy and put in a titanium knee replacement. In March, after 4months of PT, with a bend of 120 degrees, my hip started to click and my knee began to hurt. It has become worse in the last few months. Now it hurts most of the time, especially when I bend it to sit or stand. Stairs are excruciating, especially going down. It hurts just to touch it lightly on the left side of the incision. (It has always been tender in this spot.). I still have a good bend. My Dr. thinks if I have an epidural shot in my back, (I have spinal stenosis), it will relieve the pain in the knee. I am not convinced. Could I be allergic to the titanium? (If indeed that is what my replacement is made of. I wonder if there are other alloys in the titanium knee replacement.) How does
    one get tested for this? My allergist says I need a sample of titanium for them to do this testing. How does one obtain that? Any help you could give me would be greatly appreciated.

  171. Patricia Harton on July 25th, 2014 3:06 am

    Shirley Cox, please read about my medical case at Steel Standing dot com. Titanium can be put and also be Titanium Alloy that has a number of others metals in the product. There is a metal allergy test also on my website. I hope this information will help you. Best to you.

  172. Pam on July 26th, 2014 6:24 pm

    Isn’t titanium just a coating over cobalt chromium? Isn’t titanium an alloy that might contain Nickel?
    Isn’t zirconium the implant with no nickel? Smith and nephew has an implant that is coated…Oxinium Oxidized Zirconium, the ceramic knee.
    I think that is nickel free… Also there is an all polyethylene tibial base plate that can be used.
    Does anyone know for sure?

  173. Larry burton on September 13th, 2014 1:13 am

    My brother had to have his tk redone after one year after it stained hot and swollen stiff and painful his doc said yea yea sure you have hurt it. Specialist in Louisville determined he was allergic to the glue as it was deteorating and running a test. New knee today on 9/11/14 guess who has to pay another share of a major expense.. Not his last doc

  174. Robert Blau on October 18th, 2014 9:51 pm

    Stacey, I suggest you have the LTT blood test.Order the test kit from Metal Testing Laboratoru located in Chicago.312-733-7121 .Email Good luck

  175. Sean Gallagher, MD on November 14th, 2014 2:20 am

    Very real problem. I’ve revised many patients to the Aesculap AS coated knee from CoCr after finding nickel allergy as well as vanadium allergies in patients via the orthopedic analysis LTT blood test – all have done well.

    The test is covered by medicare, not usually by private payors. Screening questions including any allergy to metal – any reaction to jewelry ie earrings/rings/braclets, or belt buckles. Its estimated 20-25% of TKA failures are due to metal allergy. Aesculap AS is the only knee system in the US to be completely covered in ceramic (zirconium nitride). Smith and Nephew Oxinium femoral component is coated (oxidized zirconium) but would require an all polyethylene tibia component to avoid exposure to nickel from the tibia metal baseplate.

  176. Kathy Cummins on November 15th, 2014 12:47 am

    Thank you Larry, Robert and Dr. Gallagher. I have been struggling for 4 years with orthos. They twist knee and say it is stationary, no worry! My health has been failing since implant went in. I have knee that never bent beyond 95, pain, cement loosening, patch test cement and epoxy resin allergies, possible ligament not bending. I have allergies to meds that do not allow my knee to bend and 2 cause rashes. The docs think I am crazy on that, but it is true, regular or natural.. After 3 years of docs, they think my implant has moved and a bone is growing. I want facts before I go through this again. I need another implant in other leg so I am SCARED and frustrated with orthos.

    Who will invent the million dollar cement and allergy test that matches this nightmare before people have to go through this nightmare???
    New ortho only wants 4 metals tested with LLT in Chicago. I am so frustrated as I think it is cement. Can you recommend what testing needs to be done to cover cement and metal possibility problem? Should a full replacement be done or have people heard of just the knee part being replaced? Medicare coverage is very new news! I was told private pay only! Thank you.

  177. Effie Burt on November 19th, 2014 12:46 am

    My doctor used the Smith and Nephew Oxiinium knee implant in Dec 2011. Rash appeared two weeks after the surgery and my knee became swollen, very red. The rash started up my leg on the knee of the implant and continue to spread over my entire body. I moved to D.C. and found out after using the Ltt blood test that I WAS ALLERGIC TO EVERYTHING Dr. Gallagher described in his statement. I plan on calling Dr Gallagher on Wed. My knee is still very sore and painful. I can’t walk up stairs without holding on the rails.
    The rash disappeared after I found out that the FDA approved the used of Leveqinn for unknown rash. After using the leviquinn for 15 days the rash slowly disappeared. My doctor was amazed when the rash disappeared.

  178. Nancy Bender on November 21st, 2014 12:39 am

    I had TKR September of 2013. Within one month, I developed a terrible sore throat (I had not been physically ill in 8 years!..not even a cold!) Was put on Augmentin, and within two days, swelling of lower legs occurred. In spite of several anti-biotics, the sore throat continued off and on for several weeks…and it still will intermittently appear. The swelling and pain have consistently increased until now I can barely walk at all. The discomfort I am now experiencing is far greater than anything experienced prior to the knee replacement. Visited my ortho yesterday… via wheelchair, and he did an ex-ray of the knee prosthetic. He stated it is properly in place, that there is no infection present, skin color is great, and that the range of motion is good. Unlike many of you, I do not have any type of a rash. He feels I need hip replacement, tho admits, defective hips will not cause lower leg swelling. When I asked if this could be a metal allergy, he stated that only 1 in 30,000 have this. I stated that I have a metal allergy to costume jewelry… what if I am that one that IS allergic? He commented…it is not likely.

    I have an appointment with an allergist on 12-15-14. Meanwhile this excessive pain and swelling make life almost unbearable. Sleep comes only in 2 to 3 hour intervals, since pain will awaken me. Cannot walk, stand, or lay down without pain. And in spite of water pills, heavy legs and swelling remains a constant companion. Have seen MD, chiropractor, ortho, rheumatologist, neurologist, vascular doctor, infectious disease doctor, and several spine specialists. There have been many blood tests, MRI’s, CT scans, ex-rays, thyroid biopsy, nerve conduction study…yet no firm diagnosis can be offered. I am at a normal weight for my height, the only abnormality found is that my Sedentation rate and ANA readings are high in blood tests. This can be an indicator of metal allergy, especially when no other cause can be found. After visiting this blog, am highly optimistic that maybe a metal allergy from the knee prosthetic is my problem. Thanks to all of you for taking the time to share your stories…its been very helpful. Should you desire, feel free to contact me at: I wish the return of your good health, and many blessings to each of you.

  179. Kathy StJohn on November 21st, 2014 1:31 pm

    Nancy, my heart breaks for you…I have had my right knee replaced twice now due to a strong allergy to the nickel in the first one. And although I feel blessed that at least my surgeon was willing to replace it, I continue to suffer to varying degrees but for different reasons that were not considered with the first replacement. When I saw the high ANA result in your post, I couldn’t not write to you about my eventual diagnosis and the reason I still suffer with a replacement that I’m NOT allergic to. You said you saw a rheumatologist but did he test you for fibromyalgia, i.e., do a trigger point test? My diagnosis of that answered a lot of questions as to why I still have problems with my knee. In addition, I have chronic low platelet count, ITP, that also plays significantly in the healing process. After my second knee replacement, even though it seemed to heal much more quickly, it remained warm to the touch and painful after only 15 minutes of sitting, standing or walking. I was told by my surgeon that the combination of fibro and low platelets (plus the dreaded menopause) cause my body to form excessive scar tissue and the new knee was full of it, causing the pain and limitations I have experienced, now 18 months post replacement, even though I have excellent ROM. It is actually more “crunchy” feeling and painful than prior to replacement and can be heard by others in the room easily when I rise from a sitting position. Even sitting for more than 30-40 minutes causes pain and a need to get up, which causes pain again within 15 minutes of standing or walking.
    My hope is that you can find the answers you need to at least begin to accept that there may be nothing you can do to alleviate the ongoing symptoms. You have had more diagnostic work-up than I did but it struck a chord with me when you mentioned a possible blood disorder with the abnormal Sedentation rate and ANA results. I wish you the best in your quest to regain your health and be pain-free!

  180. Donna Johnson on November 25th, 2014 8:13 am

    I had a knee replacement on july22,2013 since then my pain is worse than before my TKR my knee does get hot and I’m seeing a pain management dr I’ve also had other unusual symptoms my white cells have dropped to 1.9 I’ve lost100 lbs which I’m glad of but I didn’t try I’ve also have neuropathy in all 4 extremities which at this time seems to be progressing very quickly could all this be related to my TKR I’m beginning to become very desperate my dr doesn’t seem to want to help me

  181. Donna Johnson on November 26th, 2014 3:04 am

    I will try again I had my TKR 7/22:2013 since then I’ve had several symptoms that are kind of unusual I’ve lost over 100lbs while I’m happy about it I haven’t tried and it just keeps coming off I also have low white cells and in the last severalomths I have developed neuropathy in all 4extremities I’ve seen an neurologist and I had an EMG which definitely have nerve damage I’m scared to death I’ve had to quit driving because I can’t feel my feet well enough to know where the pedals are and they were slipping off the pedals it feels like it’s spreading so fast also my knee hurts worse now than before my TKR my knee gets very hot to the touch it gives out all the time my pain man agent dr has concerns about this I’ve asked my orthodox dr and he just keeps saying it can’t be because of theTKR he’s obviously isn’t going to help me can anyone shed some light on this? I’m not sure my email works because I’ve never gotten any mail we might have to connect via phone or text I’m desperate so I qui put my number here 5405832753 thankyou

  182. Nancy on December 1st, 2014 3:43 am

    Donna…you may want to be tested to see if you could have an allergy to the knee prosthetic. I am in the process of doing the same. So sorry for you, the pain is almost unbearable. Please keep posting, many of us will be following your progress and keeping you in our prayers.

  183. Christie on January 20th, 2015 12:24 pm

    I had TKR on April 29, 2014. Since then, I’ve experienced hives, all sorts of gastric disturbances, sensitivity to supplements that I’ve taken for years, and my fingernails crack and peel. I’m now allergic to dogs (I’ve had the same kind of dogs for over 20 years…sometimes 3, but currently 2 beagles in residence) and I’ve been diagnosed with alopecia (bald spots on scalp). All my life I’ve been super healthy and never experienced anything like these last 8 months.

  184. Kathy Cummins on January 21st, 2015 2:55 am

    Christie, I am sorry for all you have been through. I am not a doctor, but have been through auto immune symptoms, allergies to meds and supplements and OTC medicine I took for years before knee implant. I have been to so many orthos and am so frustrated. My body is falling apart after 4 years. My knee never bent, was in constant pain and had auto immune problems 2 months after implant. All I ever heard from orthos was let me twist your leg. It did so they said it is not loose, see you in a couple of years.

    I now have cement falling out, bone growing in its pace and such difficulty walking. I need a new revision and have been trying to find Boston, MA doc who believes. There is no true metal cement allergy test they all tell me. I know my body and I was healthy before this surgery. I even had to quit my job. I will give you my email at end if you want to contact me. I have conversed with several people on this site. Two docs said this ortho problem is like the silicone problem docs knew about for years, but waited till they found new materials. It is a real problem with implants causing problems. It does not happen to everyone, but the numbers are increasing. It is a big business so the few who suffer are not important!!!

    I was going to write before I saw this entry. I am looking for anyone in the Boston, MA area who had metal or cement allergy or sensitivity. What doctor did you use who was willing to commit to finding the right products to replace? I need a revision and another knee implant so I am petrified and hope I will be able to walk. I am soooo sick of docs who say I don’t know or I have a good business and do not have time to get involved with allergy/ cement problems. Many will not even look at other docs’ X-rays or bone scans that show proof of failure. Constant pain and not bending as well as reaction to meds should raise a red flag to some caring, interested doctor. I think he/ she would need to be young or into research. Please feel free to contact me at
    Thank you!

  185. Bob on April 1st, 2015 4:30 am

    I have had TKR and now they have done a metal allergy test. It say my known stimulant PHA is off the charts. What does that mean?

  186. Stephanie on May 14th, 2015 12:40 am

    My mom had a tkr in 2009, which never worked correctly. From the start her recovery took longer than those with her in hospital and then after 1.5 yrs. of limited mobility, pain and huge swelling her surgeon tested and it was loose, great, do a revision and it will be fine, this in 2011! Well, for the past 4 yrs her issues have continued with mounting all over body pain, minimal mobility and systemic inflammation… No answers for her from the surgeon other than he doesn’t understand and is sorry, “this happens sometimes” (but rarely, right)! Through a recent blood test we found out she is allergic to the titanium and that this is more than likely the health decline she’s experienced over the past 4 yrs. A specialist at a reputable surgery hospital is going to consult with her on options, my concern, will insurance pay for this 3rd revision?

  187. Barb on July 20th, 2015 8:09 pm

    I don’t know what you mean by “Website” request on this page. However, I will also explain my predicament regarding PKR. To Kathy Cummins, I am having the same problem. My deepest sympathy to you and all the others here that are having a reaction to knee replacements. I was operated on Aug 2014 and have had severe pain in both “partial knee replacements” Makoplasty, Swelling, rash, hives, itching, loss of weight, out of breath at times, stomach problems, walking is unbearable. I have to use crutches to get around. First and foremost the doctors are not concerned for fear of law suits. They act as if you are making this up. I feel that some of you may be allergic to the cement in the bone replacement, a by product of this cement is Poly Methl methacrylate a chemical compound. I am allergic to acrylic and therefore have just found the PMMA is in the cement. I have not been tested for metals and will be requesting this ASAP. Are there any lawyers out there that could represent us as a group. This is the most painful experience in my life and I am sure all of you are in pain as well. Please let me know if you have found an answer or a doctor that has relieved your pain and/or if you have had another surgery to alleviate your pain. I can’t believe there are so many people out here with this problem and it is being ignored by the medical profession.

  188. Ruthieruth on August 29th, 2015 2:40 am

    so, I had a TKR, got really great flexion and extension from the get go. My problem has been that my ligaments keep pulling out. My comment is this. I found out later on, after my knee replacement, during unrelated allergy testing for pollen and dust etc that i have dermatagraphic skin. EVERYTHING makes me itch. I had to have my breast implants out, partly due to a mechanical complication from the implant that was messing up my hands, but also because of terrible, non stop itching under the skin that stopped pretty much when I woke up from the removal surgery. I also itch terribly from most medical plastic and adhesives. Lately, my TKR, which was done in 2009 has also started itching, and i am allergic to nickel. there is a small amount of plastic in the TKR. im just putting this out there that it may be possible while, not a true allergy, that the body can be hecka uncomfortable with foreign stuff in it! Especially for those of us who have super sensitive skin!

  189. william sitz on September 5th, 2015 5:24 am

    2012 I had my right knee replace soon after I got a rash on the outside of knee and gave me some vanicream 227gm/tmcl 0.1 2014 I had my knee replace and same rash on out side left leg showed up and it don’t go away

  190. Peggy Kendall on September 19th, 2015 6:35 pm

    I had TKR 6/2014 and have been in severe pain ever since. The doctor that did the surgery said I could be experiencing phantom pain. The next appointment was after the physical therapist said I needed to go back to see the doctor because something is really wrong…… he said that the implant was fine and that some people just too longer to heal. Then I went to a pain management doctor that thought I had nerve damage. Had two nerve blocks and no relief. She then thought it was probably coming from my spine and did two nerve blocks there and no relief. She then sent me to a back doctor. He said I needed surgery! WHAT, I have no back pain! Second opinion, no surgery! Went to another orthopedic doctor that referred me to a neurosurgeon. Thank God had compassion and saw my pain as real and serious. He was furious! IT IS NOT MY BACK was his analysis and asked if I would like to be referred to an “ethical doctor”? This new doctor tested for infection which came back negative and now having me do the test for metal and cement allergies. After reading this blog, I am convinced the mystery is going to be solved.

  191. Pam on October 8th, 2015 6:37 pm

    I had many concerns about joint replacement surgery since I am highly allergic to nickel, vanadium and medical adhesives. I didn’t have surgery for many years because I was so afraid after reading posts here. It got to a point that I could hardly walk. Finally after researching implants (and doctors) I had the surgery with the Smith and Nephew implant (see my above post July 26, 2014) on August 22, 2014. I have no nickel or vanadium in my implant. I have no pain, itching or rash.
    I did loose a significant amount of hair (alopecia) which is from the severe trauma of surgery and blood thinners.
    I hope this can help.

  192. margaret r. on November 17th, 2015 1:06 am

    I am a 71 year old female in good health. I had a TKR in July 2014. I had tremendous pain and swelling and limited use of my knee for about 7 months. They did a LTT ( lymphocyte transformation test) which showed high metal sensitivities.
    A revision was done in March 2015 with the Smith and Nephew Oxiinium. Swelling and hematoma appeared about 10 weeks after. Another surgery was done to clean out the hematoma and remove scar tissue in July 2015. About 9 weeks after that the hematoma came back with extreme swelling and pain. The doctors are perplexed.
    No solution. Any reactions like this to Smith and Nephew Oxinium?

  193. Kathy Cummins on January 16th, 2016 11:28 pm

    Thank you to all who have shared their ortho journey. Barb, I wonder if you found any more information on cement allergy. You were right on with the cement. I would also add that I found out from testing and a diagnostician that medicines can have methacrylate in them, used as a binder. The FDA does not have to reveal that. I was told this can be a problem for stomach trouble and knee replacement not bending. I thought it strange I could take some OTC meds, some prescriptions and vitamins before TKR, but had difficulty after. Every doctor thought it was in my head for 4 years of trouble till I met a wonderful, brilliant doctor. I tried to get a list of inactive ingredients That can be part of implants and do not have to be listed I was told. Contact me if you know of an ortho dealing with cement solutions or research or need to hear more of my journey!

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